Comparison of outcomes between neuroendocrine thymic tumours and other subtypes of thymic carcinomas: a joint analysis of the European Society of Thoracic Surgeons and the International Thymic Malignancy Interest GroupaEuro

被引：37

作者：

Filosso, Pier Luigi ^{[1
]}

Yao, Xiaopan ^{[2
]}

Ruffini, Enrico ^{[1
]}

Ahmad, Usman ^{[3
]}

Antonicelli, Alberto ^{[4
]}

Huang, James ^{[3
]}

Guerrera, Francesco ^{[1
]}

Venuta, Federico ^{[5
]}

van Raemdonck, Dirk ^{[6
]}

Travis, William ^{[7
]}

Lucchi, Marco ^{[8
]}

Rimner, Andreas ^{[9
]}

Thomas, Pascal ^{[10
,11
]}

Weder, Walter ^{[12
]}

Rocco, Gaetano ^{[13
]}

Detterbeck, Frank ^{[4
]}

Korst, Robert ^{[14
]}

机构：

[1] Univ Turin, Dept Thorac Surg, Turin, Italy

[2] Yale Univ, Sch Med, Sect Med Oncol, New Haven, CT USA

[3] Mem Sloan Kettering Canc Ctr, Div Thorac Surg, 1275 York Ave, New York, NY 10021 USA

[4] Yale Univ, Sch Med, Dept Thorac Surg, New Haven, CT USA

[5] Univ Rome Sapienza, Fdn Eleonora Lorillard Spencer Cenci, Policlin Umberto 1, Dept Thorac Surg, Rome, Italy

[6] Univ Hosp Leuven Belgium, Dept Thorac Surg, Leuven, Belgium

[7] Mem Sloan Kettering Canc Ctr, Dept Pathol, 1275 York Ave, New York, NY 10021 USA

[8] Univ Pisa, Pisa, Italy

[9] Mem Sloan Kettering Canc Ctr, Dept Radiat Oncol, 1275 York Ave, New York, NY 10021 USA

[10] Aix Marseille Univ, Dept Thorac Surg Lung Transplantat & Dis, Esophagus Marseille, Marseille, France

[11] Hosp Syst Marseille, AP HM, Marseille, France

[12] Univ Zurich Hosp, Div Thorac Surg, Zurich, Switzerland

[13] Pascale Fdn, Ist Nazl Tumori, IRCCS, Naples, Italy

[14] Valley Hlth Syst, Ridgewood, NJ USA

来源：

EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY | 2016年 / 50卷 / 04期

关键词：

Thymus; Thymic epithelial tumours; Thymic carcinoma; Thymic neuroendocrine tumour; Surgery; Survival; Histology; MULTICENTER EXPERIENCE; EPITHELIAL TUMORS; STAGING SYSTEM; SURVIVAL; THYMOMAS;

D O I：

10.1093/ejcts/ezw107

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The latest World Health Organization (WHO) histological classification divides thymic epithelial tumours in thymomas and thymic carcinomas (TCs), the latter also including the neuroendocrine thymic tumours (NETTs). NETTs and other TC histotypes have been described to have a significantly lower survival than thymomas, but these two groups of tumours have rarely been compared directly. Using the European Society of Thoracic Surgeons and the International Thymic Malignancy Interest Group datasets, we wanted to study this issue. This is a retrospective multicentre cohort study of patients operated for TC. Outcome measures were overall survival (OS) and recurrence-free survival (RFS). OS was analysed using the Kaplan-Meier method and RFS was assessed using competing risk analysis. The association with clinical and prognostic factors for OS and RFS was evaluated with log-rank test and Gray's test, respectively. A total of 1247 tumours (1042 TCs) were collected between 1984 and 2012. A R0 resection was performed in 363 TCs and in 52 NETTs. The median follow-up was 4.4 years for TCs and 4.1 years for NETTs. Owing to the missing values for survival information, a total of 728 TC patients and 132 NETTs were included in the OS analysis. Among them, 262 TC and 39 NETT patients died. The median OS was 6.6 years for TC and 7.5 years for NETTs. The overall 5-year survival rates were 60% for TC and 68% for NETTs; 10-year survival rates were 40% for TCs and 39% for NETTs (P = 0.19). Five-year RFS was 0.35 and 0.34 for TCs and NETTs (P = 0.36). On multivariate analysis, histology did not influence either OS (P = 0.79) or RFS (P = 0.59). This represents the largest clinical series of TCs and NETTs collected. Despite the biological aggressiveness of these rare neoplasms, the 5-year survival rate after resection is over 60% and TCs and NETT showed a similar rate of survival and recurrences after surgery.

引用

页码：766 / 771

页数：6

共 21 条

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