The Synthesis and Responsive Properties of Novel Glucose-Responsive Microgels

被引：3

作者：

Wu, Qian ^{[1
]}

Wang, Li ^{[1
]}

Yu, Haojie ^{[1
]}

Chen, Zhefu ^{[1
]}

机构：

[1] Zhejiang Univ, State Key Lab Chem Engn, Dept Chem & Biol Engn, Hangzhou 310027, Zhejiang, Peoples R China

来源：

POLYMER SCIENCE SERIES A | 2012年 / 54卷 / 03期

关键词：

PHENYLBORONIC ACID; DRUG-DELIVERY; INSULIN DELIVERY; CAPSULES; RELEASE; SYSTEM; GEL; PH;

D O I：

10.1134/S0965545X12030091

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A novel routine for preparing of glucose-responsive microgels was developed. Following the routine of copolymerizing two functional monomers, a series of microgels with phenylboronic acid dispersed inside were prepared. The thermo-behavior of the microgel was tested, which revealed the retaining property of the thermo-responsive monomer after polymerization. In addition, the glucose-responsive behavior under different temperatures and pH values were also researched. It was demonstrated that the novel microgel was able to response to glucose. Furthermore, it was found that the swelling behavior of the microgel caused by glucose was enhanced, which benefited the drug release of the system.

引用

页码：209 / 213

页数：5

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