The pathogenesis of psoriasis: Immunological facts and speculations

被引：239
作者：
Bos, JD [1 ]
De Rie, MA [1 ]
机构：
[1] Univ Amsterdam, Acad Med Ctr, Dept Dermatol, NL-1100 DE Amsterdam, Netherlands
来源：
IMMUNOLOGY TODAY | 1999年 / 20卷 / 01期
关键词：
D O I：
10.1016/S0167-5699(98)01381-4
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A central tenet of the T-cell hypothesis of psoriasis is that lymphocytes can change epidermal growth homeostasis, leading to increased keratinocyte proliferation and abnormal differentiation of these apoptotic cells that end their life cycles as corneocytes. Here, Jan Bos and Menno De Rie discuss the possibility that T cells directly activate vesting keratinocyte stem cells, through as yet undefined soluble mediators.
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页码：40 / 46
页数：7
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