Possible Adrenal Involvement in Long COVID Syndrome

被引:22
作者
Salzano, Ciro [1 ]
Saracino, Giovanna [2 ]
Cardillo, Giuseppe [2 ]
机构
[1] San Giovanni Bosco Hosp, Unit Internal Med, ASL NA1, Via Filippo Maria Briganti 255, I-80144 Naples, Italy
[2] Medylab Adv Biochem, Viale Martiri Nassiriya 14, I-81030 Lusciano, Italy
来源
MEDICINA-LITHUANIA | 2021年 / 57卷 / 10期
关键词
Long COVID; salivary cortisol and DHEA-S; adrenal insufficiency; CORTISOL;
D O I
10.3390/medicina57101087
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: A significant number of patients with COVID-19 experience prolonged symptoms, known as Long COVID. The most frequent symptoms are fatigue and cognitive dysfunction. We describe a patient suffering from Long COVID in whom adrenal involvement was highlighted. Methods: The patient described Long COVID symptoms that persist 3 months after the negativization of the molecular swab test. The main symptoms were weakness, brain fog, dizziness, and muscular and joint pain. All routine lab panels for inflammation, anemia, and thyroid and liver function were conducted. Moreover, salivary cortisol and DHEA-S determinations were used to compute the adrenal stress index (ASI). Results: All tests were negative, except the ASI that showed very low levels of free cortisol. The patient started hydrocortisone acetate supplementation. Conclusion: Long COVID symptoms could be explained by an adrenal involvement, due to a COVID-19 action on adrenal glands and by a iatrogenic side effect of high glucocorticoid therapy during the COVID-19 infection. Salivary cortisol determination is effective for establishing a correct recovery plan.
引用
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页数:6
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