Gut microbiome and pediatric multiple sclerosis

被引：24

作者：

Tremlett, Helen ^{[1
,2
]}

Waubant, Emmanuelle ^{[3
]}

机构：

[1] Univ British Columbia, Djavad Mowafaghian Ctr Brain Hlth, Vancouver, BC, Canada

[2] Univ British Columbia, Fac Med, Div Neurol, Vancouver, BC, Canada

[3] Univ Calif San Francisco, San Francisco, CA 94143 USA

来源：

MULTIPLE SCLEROSIS JOURNAL | 2018年 / 24卷 / 01期

关键词：

Microbiome; microbiota; disease-modifying therapies; case-control; pediatric multiple sclerosis; relapse risk;

D O I：

10.1177/1352458517737369

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Half of our cells and only 1 in 100 of our genes are human; the rest comprise microbes, termed the human microbiota. Over 90% of these microbes live in the large intestine. Aside from aiding food digestion, these diverse microbes can also synthesize essential vitamins or amino acids, educate and modulate the immune system response, and influence susceptibility or resistance to infections. Their potential to influence neurological conditions such as multiple sclerosis (MS) is intriguing. The overarching goal of this Americas Committee for Treatment and Research in Multiple Sclerosis (ACTRIMS) presentation was to provide a high-level insight into gut microbiota's potential role in pediatric MS. Two specific questions were also addressed based on published work: (1) Does the gut microbiota differ between children with and without MS? and (2) Is the gut microbiota associated with future relapse risk?

引用

页码：64 / 68

页数：5

共 19 条

[1] Microbes and the mind: emerging hallmarks of the gut microbiota-brain axis [J].

Bauer, Kylynda C. ;

Huus, Kelsey E. ;

Finlay, B. Brett .

CELLULAR MICROBIOLOGY, 2016, 18 (05) :632-644

[2] Microbial view of central nervous system autoimmunity [J].

Berer, Kerstin ;

Krishnamoorthy, Gurumoorthy .

FEBS LETTERS, 2014, 588 (22) :4207-4213

[3] Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination [J].

Berer, Kerstin ;

Mues, Marsilius ;

Koutrolos, Michail ;

Al Rasbi, Zakeya ;

Boziki, Marina ;

Johner, Caroline ;

Wekerle, Hartmut ;

Krishnamoorthy, Gurumoorthy .

NATURE, 2011, 479 (7374) :538-U266

[4] Gut Microbiota in Multiple Sclerosis: Possible Influence of Immunomodulators [J].

Cantarel, Brandi L. ;

Waubant, Emmanuelle ;

Chehoud, Christel ;

Kuczynski, Justin ;

DeSantis, Todd Z. ;

Warrington, Janet ;

Venkatesan, Arun ;

Fraser, Claire M. ;

Mowry, Ellen M. .

JOURNAL OF INVESTIGATIVE MEDICINE, 2015, 63 (05) :729-734

[5] Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls [J].

Chen, Jun ;

Chia, Nicholas ;

Kalari, Krishna R. ;

Yao, Janet Z. ;

Novotna, Martina ;

Soldan, M. Mateo Paz ;

Luckey, David H. ;

Marietta, Eric V. ;

Jeraldo, Patricio R. ;

Chen, Xianfeng ;

Weinshenker, Brian G. ;

Rodriguez, Moses ;

Kantarci, Orhun H. ;

Nelson, Heidi ;

Murray, Joseph A. ;

Mangalam, Ashutosh K. .

SCIENTIFIC REPORTS, 2016, 6

[6] Gut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration [J].

Dinan, Timothy G. ;

Cryan, John F. .

JOURNAL OF PHYSIOLOGY-LONDON, 2017, 595 (02) :489-503

[7] Alterations of the human gut microbiome in multiple sclerosis [J].

Jangi, Sushrut ;

Gandhi, Roopali ;

Cox, Laura M. ;

Li, Ning ;

von Glehn, Felipe ;

Yan, Raymond ;

Patel, Bonny ;

Mazzola, Maria Antonietta ;

Liu, Shirong ;

Glanz, Bonnie L. ;

Cook, Sandra ;

Tankou, Stephanie ;

Stuart, Fiona ;

Melo, Kirsy ;

Nejad, Parham ;

Smith, Kathleen ;

Topcuolu, Begum D. ;

Holden, James ;

Kivisakk, Pia ;

Chitnis, Tanuja ;

De Jager, Philip L. ;

Quintana, Francisco J. ;

Gerber, Georg K. ;

Bry, Lynn ;

Weiner, Howard L. .

NATURE COMMUNICATIONS, 2016, 7

[8] Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences [J].

Langille, Morgan G. I. ;

Zaneveld, Jesse ;

Caporaso, J. Gregory ;

McDonald, Daniel ;

Knights, Dan ;

Reyes, Joshua A. ;

Clemente, Jose C. ;

Burkepile, Deron E. ;

Thurber, Rebecca L. Vega ;

Knight, Rob ;

Beiko, Robert G. ;

Huttenhower, Curtis .

NATURE BIOTECHNOLOGY, 2013, 31 (09) :814-+

[9] Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis [J].

Lee, Yun Kyung ;

Menezes, Juscilene S. ;

Umesaki, Yoshinori ;

Mazmanian, Sarkis K. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 :4615-4622

[10] Dysbiosis in the Gut Microbiota of Patients with Multiple Sclerosis, with a Striking Depletion of Species Belonging to Clostridia XIVa and IV Clusters [J].

Miyake, Sachiko ;

Kim, Sangwan ;

Suda, Wataru ;

Oshima, Kenshiro ;

Nakamura, Masakazu ;

Matsuoka, Takako ;

Chihara, Norio ;

Tomita, Atsuko ;

Sato, Wakiro ;

Kim, Seok-Won ;

Morita, Hidetoshi ;

Hattori, Masahira ;

Yamamura, Takashi .

PLOS ONE, 2015, 10 (09)

← 1 2 →