Palladium-Catalyzed Direct C-H Arylation of Isoxazoles at the 5-Position

被引：44
|
作者：
Shigenobu, Masashi [1 ]
Takenaka, Kazuhiro [1 ]
Sasai, Hiroaki [1 ]
机构：
[1] Osaka Univ, ISIR, Osaka 5670047, Japan
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2015年 / 54卷 / 33期
关键词：
arylation; C-H activation; cross-coupling; heterocycles; palladium; CARBON-CARBON BONDS; REDUCTIVE ELIMINATION; HETEROAROMATIC-COMPOUNDS; NITRILE OXIDES; FUNCTIONALIZATION; HYDROGEN; CONSTRUCTION; ACTIVATION; CYCLOADDITION; EFFICIENT;
D O I：
10.1002/anie.201504552
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A palladium-catalyzed direct arylation of isoxazoles with aryl iodides has been achieved. The CH bond at the 5-position is activated selectively to give coupling products in moderate to good yields. This direct arylation was applied to the synthesis of a spiro-type chiral ligand, which proved to be most effective to the palladium-catalyzed tandem cyclization of a dialkenyl alcohol.
引用
收藏
页码：9572 / 9576
页数：5
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