Oxidative and nitrative protein modifications in Parkinson's disease

被引：171

作者：

Danielson, Steven R. ^{[1
]}

Andersen, Julie K. ^{[1
]}

机构：

[1] Buck Inst Age Res, Novato, CA 94945 USA

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 2008年 / 44卷 / 10期

关键词：

oxidation; nitration; HNE; 3NT; posttranslational modification; Parkinson's disease;

D O I：

10.1016/j.freeradbiomed.2008.03.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Parkinson's disease (PD) is a complex neurodegenerative syndrome likely involving contributions from various factors in individuals including genetic susceptibility, exposure to environmental toxins, and the aging process itself. Increased oxidative stress appears to be a common causative aspect involved in the preferential loss of dopaminergic neurons in a region of the brain prominently affected by the disorder, the substantia nigra (SN). Loss of dopaminergic SN neurons is responsible for the classic clinical motor symptoms associated with PD. Several oxidative and nitrative posttranslational modifications (PTMs) have been identified on proteins pertinent to PD that may affect this or other aspects of disease progression. In this review, we discuss several examples of such PTMs to illustrate their potential consequences in terms of initiation or progression of PD neuropathophysiology. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：1787 / 1794

页数：8

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