Impairment of 3000-m Run Time at Altitude Is Influenced by Arterial Oxyhemoglobin Saturation

CHAPMAN, R. F., J. M. STAGER, D. A. TANNER, J. STRAY-GUNDERSEN, and B. D. LEVINE. Impairment of 3000-m Run Time at Altitude Is Influenced by Arterial Oxyhemoglobin Saturation. Med. Sci. Sports Exerc., Vol. 43, No. 9, pp. 1649-1656, 2011. The decline in maximal oxygen uptake (Delta(V) over dotO(2max)) with acute exposure to moderate altitude is dependent on the ability to maintain arterial oxyhemoglobin saturation (SaO(2)). Purpose: This study examined if factors related to Delta(V) over dotO(2max) at altitude are also related to the decline in race performance of elite athletes at altitude. Methods: Twenty-seven elite distance runners (18 men and 9 women, (V) over dotO(2max) = 71.8 +/- 7.2 mL.kg(-1).min(-1)) performed a treadmill exercise at a constant speed that simulated their 3000-m race pace, both in normoxia and in 16.3% O(2) (similar to 2100 m). Separate 3000-m time trials were completed at sea level (18 h before altitude exposure) and at 2100 m (48 h after arrival at altitude). Statistical significance was set at P <= 0.05. Results: Group 3000-m performance was significantly slower at altitude versus sea level (48.5 +/- 12.7 s), and the declines were significant in men (48.4 +/- 14.6 s) and women (48.6 +/- 8.9 s). Athletes grouped by low SaO(2) during race pace in normoxia (SaO(2) <91%, n = 7) had a significantly larger Delta(V) over dotO(2) in hypoxia (-9.2 +/- 2.1 mL.kg(-1).min(-1)) and Delta 3000-m time at altitude (54.0 +/- 13.7 s) compared with athletes with high SaO(2) in normoxia (SaO(2) > 93%, n = 7, Delta(V) over dotO(2) = -3.5 +/- 2.0 mL.kg(-1).min(-1), Delta 3000-m time = 38.9 +/- 9.7 s). For all athletes, SaO(2) during normoxic race pace running was significantly correlated with both Delta(V) over dotO(2) (r = -0.68) and Delta 3000-m time (r = -0.38). Conclusions: These results indicate that the degree of arterial oxyhemoglobin desaturation, already known to influence Delta(V) over dotO(2max) at altitude, also contributes to the magnitude of decline in race performance at altitude.