A trypanocidal diterpene with novel skeleton from Dracocephalum komarovi

被引：37

作者：

Uchiyama, N

Ito, M

Kiuchi, F

Honda, G ^{[1
]}

Takeda, Y

Khodzhimatov, OK

Ashurmetov, OA

机构：

[1] Kyoto Univ, Grad Sch Pharmaceut Sci, Kyoto 6068501, Japan

[2] Natl Inst Hlth Sci, Tsukuba Med Plant Res Stn, Tsukuba, Ibaraki 3050843, Japan

[3] Univ Tokushima, Fac Integrated Arts & Sci, Tokushima 7708502, Japan

[4] Uzbek Acad Sci, Sci Prod Ctr Bot, Tashkent 700143, Uzbekistan

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 03期

基金：

日本学术振兴会;

关键词：

Dracocephalum komarovi; diterpene; spiro lactone; Trypanosoma cruzi; trypanocidal activity;

D O I：

10.1016/j.tetlet.2003.10.202

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new diterpene, komarovispirone (1) with a spiro-octahydroindene skeleton, was isolated from Dracocephalum komarovi. The structure was elucidated by extensive analyses of spectral data. Komarovispirone (1) showed trypanocidal activity against epimastigote of Trypanosoma cruzi, the causative agent of American trypanosomiasis, with a minimum lethal concentration of 23 muM. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：531 / 533

页数：3

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