Genetics of Male Infertility

被引：60
作者：
Lira Neto, Filipe Tenorio [1 ,2 ]
Phil Vu Bach [1 ,2 ]
Najari, Bobby Baback [1 ,2 ]
Li, Philip Shihua [1 ,2 ]
Goldstein, Marc [1 ,2 ]
机构：
[1] Weill Cornell Med Coll, Ctr Male Reprod Med & Microsurg, Dept Urol, New York, NY 10065 USA
[2] Weill Cornell Med Coll, Inst Reprod Med, New York, NY 10065 USA
来源：
CURRENT UROLOGY REPORTS | 2016年 / 17卷 / 10期
关键词：
Male infertility; Genetics; Epigenetics; Reproduction; CONGENITAL BILATERAL ABSENCE; Y-CHROMOSOME MICRODELETIONS; INTRACYTOPLASMIC SPERM INJECTION; SEMINAL PLASMA MICRORNAS; KLINEFELTER-SYNDROME; VAS-DEFERENS; DNA METHYLATION; CFTR GENE; HYPOGONADOTROPIC HYPOGONADISM; POTENTIAL BIOMARKERS;
D O I：
10.1007/s11934-016-0627-x
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
While 7 % of the men are infertile, currently, a genetic etiology is identified in less than 25 % of those men, and 30 % of the infertile men lack a definitive diagnosis, falling in the "idiopathic infertility" category. Advances in genetics and epigenetics have led to several proposed mechanisms for male infertility. These advances may result in new diagnostic tools, treatment approaches, and better counseling with regard to treatment options and prognosis. In this review, we focus on clinical aspects of male infertility and the role of genetics in elucidating etiologies and the potential of treatments.
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页数：12
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