共 101 条
Nuclear lamina remodelling and its implications for human disease
被引:20
作者:

Chojnowski, Alexandre
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机构:
Inst Med Biol, Dev & Regenerat Biol, Singapore 138648, Singapore Inst Med Biol, Cellular Ageing, Singapore 138648, Singapore

Ong, Peh Fern
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机构:
Inst Med Biol, Cellular Ageing, Singapore 138648, Singapore Inst Med Biol, Cellular Ageing, Singapore 138648, Singapore

Dreesen, Oliver
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机构:
Inst Med Biol, Cellular Ageing, Singapore 138648, Singapore Inst Med Biol, Cellular Ageing, Singapore 138648, Singapore
机构:
[1] Inst Med Biol, Cellular Ageing, Singapore 138648, Singapore
[2] Inst Med Biol, Dev & Regenerat Biol, Singapore 138648, Singapore
关键词:
Lamin A/C;
Lamin B1;
Laminopathies;
Lamina remodelling;
Hutchinson-Gilford progeria syndrome;
Autosomal dominant leukodystrophy;
B-TYPE LAMINS;
A-TYPE LAMIN;
TELOMERE LENGTH;
A/C EXPRESSION;
FARNESYLATION INHIBITORS;
MAMMALIAN-CELLS;
MOUSE;
PROTEIN;
DEFECTS;
ARCHITECTURE;
D O I:
10.1007/s00441-014-2069-4
中图分类号:
Q2 [细胞生物学];
学科分类号:
071009 ;
090102 ;
摘要:
The intermediate filament A- and B-type lamins are key architectural components of the nuclear lamina, a protein-aceous meshwork that lies underneath the inner nuclear membrane. In the past decade, many different monogenic human diseases have been linked to mutations in various components of the nuclear lamina. Mutations in LMNA (encoding lamin A and C) cause a variety of human diseases, collectively called laminopathies. These include cardiomyopathies, muscular dystrophies, lipodystrophies and progeroid syndromes. In addition, elevated levels of lamin B1, attributable to genomic duplications of the LMNB1 locus, cause adult-onset autosomal dominant leukodystrophy. The molecular mechanism(s) enabling themutations and perturbations of the nuclear lamina to give rise to such a wide variety of diseases that affect various tissues remains unclear. The composition of the nuclear lamina changes dynamically during development, between cell types and even within the same cell during differentiation and ageing. Here, we discuss the functional and cellular aspects of lamina remodelling and their implications for the tissue-specific nature of laminopathies.
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页码:621 / 631
页数:11
相关论文
共 101 条
[1]
TELOMERE LENGTH PREDICTS REPLICATIVE CAPACITY OF HUMAN FIBROBLASTS
[J].
ALLSOPP, RC
;
VAZIRI, H
;
PATTERSON, C
;
GOLDSTEIN, S
;
YOUNGLAI, EV
;
FUTCHER, AB
;
GREIDER, CW
;
HARLEY, CB
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1992, 89 (21)
:10114-10118

ALLSOPP, RC
论文数: 0 引用数: 0
h-index: 0
机构: MCMASTER UNIV,DEPT BIOCHEM,1200 MAIN ST W,HAMILTON L8N 3Z5,ONTARIO,CANADA

VAZIRI, H
论文数: 0 引用数: 0
h-index: 0
机构: MCMASTER UNIV,DEPT BIOCHEM,1200 MAIN ST W,HAMILTON L8N 3Z5,ONTARIO,CANADA

PATTERSON, C
论文数: 0 引用数: 0
h-index: 0
机构: MCMASTER UNIV,DEPT BIOCHEM,1200 MAIN ST W,HAMILTON L8N 3Z5,ONTARIO,CANADA

GOLDSTEIN, S
论文数: 0 引用数: 0
h-index: 0
机构: MCMASTER UNIV,DEPT BIOCHEM,1200 MAIN ST W,HAMILTON L8N 3Z5,ONTARIO,CANADA

YOUNGLAI, EV
论文数: 0 引用数: 0
h-index: 0
机构: MCMASTER UNIV,DEPT BIOCHEM,1200 MAIN ST W,HAMILTON L8N 3Z5,ONTARIO,CANADA

FUTCHER, AB
论文数: 0 引用数: 0
h-index: 0
机构: MCMASTER UNIV,DEPT BIOCHEM,1200 MAIN ST W,HAMILTON L8N 3Z5,ONTARIO,CANADA

GREIDER, CW
论文数: 0 引用数: 0
h-index: 0
机构: MCMASTER UNIV,DEPT BIOCHEM,1200 MAIN ST W,HAMILTON L8N 3Z5,ONTARIO,CANADA

HARLEY, CB
论文数: 0 引用数: 0
h-index: 0
机构: MCMASTER UNIV,DEPT BIOCHEM,1200 MAIN ST W,HAMILTON L8N 3Z5,ONTARIO,CANADA
[2]
Reshaping of the endoplasmic reticulum limits the rate for nuclear envelope formation
[J].
Anderson, Daniel J.
;
Hetzer, Martin W.
.
JOURNAL OF CELL BIOLOGY,
2008, 182 (05)
:911-924

Anderson, Daniel J.
论文数: 0 引用数: 0
h-index: 0
机构:
Salk Inst Biol Studies, Mol & Cell Biol Lab, La Jolla, CA 92037 USA Salk Inst Biol Studies, Mol & Cell Biol Lab, La Jolla, CA 92037 USA

Hetzer, Martin W.
论文数: 0 引用数: 0
h-index: 0
机构:
Salk Inst Biol Studies, Mol & Cell Biol Lab, La Jolla, CA 92037 USA Salk Inst Biol Studies, Mol & Cell Biol Lab, La Jolla, CA 92037 USA
[3]
Nuclear envelope formation by chromatin-mediated reorganization of the endoplasmic reticulum
[J].
Anderson, Daniel J.
;
Hetzer, Martin W.
.
NATURE CELL BIOLOGY,
2007, 9 (10)
:1160-1166

Anderson, Daniel J.
论文数: 0 引用数: 0
h-index: 0
机构:
Salk Inst Biol Studies, Mol Cell Biol Lab, La Jolla, CA 92037 USA Salk Inst Biol Studies, Mol Cell Biol Lab, La Jolla, CA 92037 USA

Hetzer, Martin W.
论文数: 0 引用数: 0
h-index: 0
机构:
Salk Inst Biol Studies, Mol Cell Biol Lab, La Jolla, CA 92037 USA Salk Inst Biol Studies, Mol Cell Biol Lab, La Jolla, CA 92037 USA
[4]
Oxidative stress induces an ATM-independent senescence pathway through p38 MAPK-mediated lamin B1 accumulation
[J].
Barascu, Aurelia
;
Le Chalony, Catherine
;
Pennarun, Gaelle
;
Genet, Diane
;
Imam, Naima
;
Lopez, Bernard
;
Bertrand, Pascale
.
EMBO JOURNAL,
2012, 31 (05)
:1080-1094

Barascu, Aurelia
论文数: 0 引用数: 0
h-index: 0
机构:
CNRS, UMR217, F-92265 Fontenay Aux Roses, France
CEA, DSV, IRCM, F-92265 Fontenay Aux Roses, France CNRS, UMR217, F-92265 Fontenay Aux Roses, France

Le Chalony, Catherine
论文数: 0 引用数: 0
h-index: 0
机构:
CNRS, UMR217, F-92265 Fontenay Aux Roses, France
CEA, DSV, IRCM, F-92265 Fontenay Aux Roses, France CNRS, UMR217, F-92265 Fontenay Aux Roses, France

Pennarun, Gaelle
论文数: 0 引用数: 0
h-index: 0
机构:
CNRS, UMR217, F-92265 Fontenay Aux Roses, France
CEA, DSV, IRCM, F-92265 Fontenay Aux Roses, France CNRS, UMR217, F-92265 Fontenay Aux Roses, France

Genet, Diane
论文数: 0 引用数: 0
h-index: 0
机构:
CNRS, UMR217, F-92265 Fontenay Aux Roses, France
CEA, DSV, IRCM, F-92265 Fontenay Aux Roses, France CNRS, UMR217, F-92265 Fontenay Aux Roses, France

Imam, Naima
论文数: 0 引用数: 0
h-index: 0
机构:
CNRS, UMR217, F-92265 Fontenay Aux Roses, France
CEA, DSV, IRCM, F-92265 Fontenay Aux Roses, France CNRS, UMR217, F-92265 Fontenay Aux Roses, France

Lopez, Bernard
论文数: 0 引用数: 0
h-index: 0
机构:
CNRS, UMR217, F-92265 Fontenay Aux Roses, France
CEA, DSV, IRCM, F-92265 Fontenay Aux Roses, France CNRS, UMR217, F-92265 Fontenay Aux Roses, France

Bertrand, Pascale
论文数: 0 引用数: 0
h-index: 0
机构:
CNRS, UMR217, F-92265 Fontenay Aux Roses, France
CEA, DSV, IRCM, F-92265 Fontenay Aux Roses, France CNRS, UMR217, F-92265 Fontenay Aux Roses, France
[5]
A lamin in lower eukaryotes?
[J].
Batsios, Petros
;
Peter, Tatjana
;
Baumann, Otto
;
Stick, Reimer
;
Meyer, Irene
;
Graef, Ralph
.
NUCLEUS,
2012, 3 (03)
:237-243

Batsios, Petros
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Potsdam, Dept Cell Biol, Inst Biochem & Biol, Potsdam, Germany Univ Potsdam, Dept Cell Biol, Inst Biochem & Biol, Potsdam, Germany

Peter, Tatjana
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Potsdam, Dept Cell Biol, Inst Biochem & Biol, Potsdam, Germany Univ Potsdam, Dept Cell Biol, Inst Biochem & Biol, Potsdam, Germany

Baumann, Otto
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Potsdam, Dept Anim Physiol, Inst Biochem & Biol, Potsdam, Germany Univ Potsdam, Dept Cell Biol, Inst Biochem & Biol, Potsdam, Germany

Stick, Reimer
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Bremen, Dept Cell Biol, D-28359 Bremen, Germany Univ Potsdam, Dept Cell Biol, Inst Biochem & Biol, Potsdam, Germany

Meyer, Irene
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Potsdam, Dept Cell Biol, Inst Biochem & Biol, Potsdam, Germany Univ Potsdam, Dept Cell Biol, Inst Biochem & Biol, Potsdam, Germany

Graef, Ralph
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Potsdam, Dept Cell Biol, Inst Biochem & Biol, Potsdam, Germany Univ Potsdam, Dept Cell Biol, Inst Biochem & Biol, Potsdam, Germany
[6]
Loss of lamin A/C expression in stage II and III colon cancer is associated with disease recurrence
[J].
Belt, E. J. Th.
;
Fijneman, R. J. A.
;
van den Berg, E. G.
;
Bril, H.
;
Delis-van Diemen, P. M.
;
Tijssen, M.
;
van Essen, H. F.
;
de lange-de Klerk, E. S. M.
;
Belien, J. A. M.
;
Stockmann, H. B. A. C.
;
Meijer, S.
;
Meijer, G. A.
.
EUROPEAN JOURNAL OF CANCER,
2011, 47 (12)
:1837-1845

Belt, E. J. Th.
论文数: 0 引用数: 0
h-index: 0
机构:
Vrije Univ Amsterdam Med Ctr, Dept Surg, NL-1081 HV Amsterdam, Netherlands Vrije Univ Amsterdam Med Ctr, Dept Pathol, NL-1081 HV Amsterdam, Netherlands

Fijneman, R. J. A.
论文数: 0 引用数: 0
h-index: 0
机构:
Vrije Univ Amsterdam Med Ctr, Dept Pathol, NL-1081 HV Amsterdam, Netherlands Vrije Univ Amsterdam Med Ctr, Dept Pathol, NL-1081 HV Amsterdam, Netherlands

van den Berg, E. G.
论文数: 0 引用数: 0
h-index: 0
机构:
Vrije Univ Amsterdam Med Ctr, Dept Pathol, NL-1081 HV Amsterdam, Netherlands Vrije Univ Amsterdam Med Ctr, Dept Pathol, NL-1081 HV Amsterdam, Netherlands

Bril, H.
论文数: 0 引用数: 0
h-index: 0
机构:
Kennemer Gasthuis, Dept Pathol, NL-2035 RC Haarlem, Netherlands Vrije Univ Amsterdam Med Ctr, Dept Pathol, NL-1081 HV Amsterdam, Netherlands

Delis-van Diemen, P. M.
论文数: 0 引用数: 0
h-index: 0
机构:
Vrije Univ Amsterdam Med Ctr, Dept Pathol, NL-1081 HV Amsterdam, Netherlands Vrije Univ Amsterdam Med Ctr, Dept Pathol, NL-1081 HV Amsterdam, Netherlands

Tijssen, M.
论文数: 0 引用数: 0
h-index: 0
机构:
Vrije Univ Amsterdam Med Ctr, Dept Pathol, NL-1081 HV Amsterdam, Netherlands Vrije Univ Amsterdam Med Ctr, Dept Pathol, NL-1081 HV Amsterdam, Netherlands

van Essen, H. F.
论文数: 0 引用数: 0
h-index: 0
机构:
Vrije Univ Amsterdam Med Ctr, Dept Pathol, NL-1081 HV Amsterdam, Netherlands Vrije Univ Amsterdam Med Ctr, Dept Pathol, NL-1081 HV Amsterdam, Netherlands

de lange-de Klerk, E. S. M.
论文数: 0 引用数: 0
h-index: 0
机构:
Vrije Univ Amsterdam Med Ctr, Dept Epidemiol & Biostat, NL-1081 HV Amsterdam, Netherlands Vrije Univ Amsterdam Med Ctr, Dept Pathol, NL-1081 HV Amsterdam, Netherlands

Belien, J. A. M.
论文数: 0 引用数: 0
h-index: 0
机构:
Vrije Univ Amsterdam Med Ctr, Dept Pathol, NL-1081 HV Amsterdam, Netherlands Vrije Univ Amsterdam Med Ctr, Dept Pathol, NL-1081 HV Amsterdam, Netherlands

Stockmann, H. B. A. C.
论文数: 0 引用数: 0
h-index: 0
机构:
Kennemer Gasthuis, Dept Surg, NL-2035 RC Haarlem, Netherlands Vrije Univ Amsterdam Med Ctr, Dept Pathol, NL-1081 HV Amsterdam, Netherlands

Meijer, S.
论文数: 0 引用数: 0
h-index: 0
机构: Vrije Univ Amsterdam Med Ctr, Dept Pathol, NL-1081 HV Amsterdam, Netherlands

Meijer, G. A.
论文数: 0 引用数: 0
h-index: 0
机构:
Vrije Univ Amsterdam Med Ctr, Dept Pathol, NL-1081 HV Amsterdam, Netherlands Vrije Univ Amsterdam Med Ctr, Dept Pathol, NL-1081 HV Amsterdam, Netherlands
[7]
Screening for Cervical Cancer Using Automated Analysis of PAP-Smears
[J].
Bengtsson, Ewert
;
Malm, Patrik
.
COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE,
2014, 2014

Bengtsson, Ewert
论文数: 0 引用数: 0
h-index: 0
机构:
Uppsala Univ, Ctr Image Anal, Dept Informat Technol, Div Visual Informat & Interact, S-75105 Uppsala, Sweden Uppsala Univ, Ctr Image Anal, Dept Informat Technol, Div Visual Informat & Interact, S-75105 Uppsala, Sweden

Malm, Patrik
论文数: 0 引用数: 0
h-index: 0
机构:
Uppsala Univ, Ctr Image Anal, Dept Informat Technol, Div Visual Informat & Interact, S-75105 Uppsala, Sweden Uppsala Univ, Ctr Image Anal, Dept Informat Technol, Div Visual Informat & Interact, S-75105 Uppsala, Sweden
[8]
Role of progerin-induced telomere dysfunction in HGPS premature cellular senescence
[J].
Benson, Erica K.
;
Lee, Sam W.
;
Aaronson, Stuart A.
.
JOURNAL OF CELL SCIENCE,
2010, 123 (15)
:2605-2612

Benson, Erica K.
论文数: 0 引用数: 0
h-index: 0
机构:
Mt Sinai Sch Med, Dept Oncol Sci, New York, NY 10012 USA Mt Sinai Sch Med, Dept Oncol Sci, New York, NY 10012 USA

Lee, Sam W.
论文数: 0 引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Cutaneous Biol Res Ctr, Charlestown, MA 02129 USA
Harvard Univ, Sch Med, Charlestown, MA 02129 USA Mt Sinai Sch Med, Dept Oncol Sci, New York, NY 10012 USA

Aaronson, Stuart A.
论文数: 0 引用数: 0
h-index: 0
机构:
Mt Sinai Sch Med, Dept Oncol Sci, New York, NY 10012 USA Mt Sinai Sch Med, Dept Oncol Sci, New York, NY 10012 USA
[9]
Both lamin A and lamin C mutations cause lamina instability as well as loss of internal nuclear lamin organization
[J].
Broers, JLV
;
Kuijpers, HJH
;
Östlund, C
;
Worman, HJ
;
Endert, J
;
Ramaekers, FCS
.
EXPERIMENTAL CELL RESEARCH,
2005, 304 (02)
:582-592

Broers, JLV
论文数: 0 引用数: 0
h-index: 0
机构: Univ Limburg, Dept Mol Cell Biol, CARIM, NL-6200 MD Maastricht, Netherlands

Kuijpers, HJH
论文数: 0 引用数: 0
h-index: 0
机构: Univ Limburg, Dept Mol Cell Biol, CARIM, NL-6200 MD Maastricht, Netherlands

Östlund, C
论文数: 0 引用数: 0
h-index: 0
机构: Univ Limburg, Dept Mol Cell Biol, CARIM, NL-6200 MD Maastricht, Netherlands

Worman, HJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Limburg, Dept Mol Cell Biol, CARIM, NL-6200 MD Maastricht, Netherlands

Endert, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Limburg, Dept Mol Cell Biol, CARIM, NL-6200 MD Maastricht, Netherlands

Ramaekers, FCS
论文数: 0 引用数: 0
h-index: 0
机构: Univ Limburg, Dept Mol Cell Biol, CARIM, NL-6200 MD Maastricht, Netherlands
[10]
A- and B-type lamins are differentially expressed in normal human tissues
[J].
Broers, JLV
;
Machiels, BM
;
Kuijpers, HJH
;
Smedts, F
;
vandenKieboom, R
;
Raymond, Y
;
Ramaekers, FCS
.
HISTOCHEMISTRY AND CELL BIOLOGY,
1997, 107 (06)
:505-517

Broers, JLV
论文数: 0 引用数: 0
h-index: 0
机构: CANISIUS WILHELMINA HOSP,DEPT PATHOL,NIJMEGEN,NETHERLANDS

Machiels, BM
论文数: 0 引用数: 0
h-index: 0
机构: CANISIUS WILHELMINA HOSP,DEPT PATHOL,NIJMEGEN,NETHERLANDS

Kuijpers, HJH
论文数: 0 引用数: 0
h-index: 0
机构: CANISIUS WILHELMINA HOSP,DEPT PATHOL,NIJMEGEN,NETHERLANDS

Smedts, F
论文数: 0 引用数: 0
h-index: 0
机构: CANISIUS WILHELMINA HOSP,DEPT PATHOL,NIJMEGEN,NETHERLANDS

vandenKieboom, R
论文数: 0 引用数: 0
h-index: 0
机构: CANISIUS WILHELMINA HOSP,DEPT PATHOL,NIJMEGEN,NETHERLANDS

Raymond, Y
论文数: 0 引用数: 0
h-index: 0
机构: CANISIUS WILHELMINA HOSP,DEPT PATHOL,NIJMEGEN,NETHERLANDS

Ramaekers, FCS
论文数: 0 引用数: 0
h-index: 0
机构: CANISIUS WILHELMINA HOSP,DEPT PATHOL,NIJMEGEN,NETHERLANDS