The Prevalence of Vitiligo: A Meta-Analysis

被引:155
作者
Zhang, Yuhui [1 ]
Cai, Yunfei [1 ]
Shi, Meihui [1 ]
Jiang, Shibin [1 ]
Cui, Shaoshan [2 ]
Wu, Yan [1 ]
Gao, Xing-Hua [1 ]
Chen, Hong-Duo [1 ]
机构
[1] China Med Univ, Hosp 1, Dept Dermatol, Shenyang 110001, Peoples R China
[2] Dalian Med Univ, Hosp 1, Dept Dermatol, Dalian 116011, Peoples R China
关键词
SKIN DISEASES; SCHOOL-CHILDREN; REPRESENTATIVE SAMPLE; DERMATOLOGICAL DISORDERS; AUTOIMMUNE-DISEASES; SAUDI-ARABIA; POPULATION; EPIDEMIOLOGY; SCHOOLCHILDREN; NIGERIA;
D O I
10.1371/journal.pone.0163806
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Objective To conduct a meta-analysis assessing the prevalence of vitiligo. Methods Literatures that reported prevalence rates of vitiligo were identified using EMBASE, PubMed, the Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang database and Weipu database for the period from inception to May 2016. We performed stratified analyses on possible sources of bias, including areas difference, years of publication, gender and age. Publication bias was assessed with Egger's test method. Results A total of 103 studies were eligible for inclusion. The pooled prevalence of vitiligo from 82 population- or community-based studies was 0.2% (95% CI: 0.1%-0.2%) and from 22 hospital-based studies was 1.8% ( 95% CI: 1.4%-2.1%). A relatively high prevalence of vitiligo was found in Africa area and in female patients. For population- or community-based studies, the prevalence has maintained at a low level in recent 20 years and it has increased with age gradually. For hospital-based studies, the prevalence has showed a decreased trend from 60s till now or from young to old. No significant publication bias existed in hospital-based studies (t = 0.47, P = 0.643), while a significant publication bias existed in population- or community-based studies ( t = 2.31, P = 0.026). Conclusion A relatively high prevalence of vitiligo was found in Africa area and in female patients. The prevalence has maintained at a low level in recent years. It showed an inverse trend with age increment in population- or community-based studies and hospital-based studies.
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页数:17
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