Refractory lung metastasis from breast cancer treated with multidisciplinary therapy including an immunological approach

被引：18
作者：
Takada, Masahiro [1 ]
Terunuma, Hiroshi [2 ,3 ]
Deng, Xuewen [2 ]
Dewan, Md. Zahidunnabi [4 ]
Saji, Shigehira [5 ]
Kuroi, Katsumasa [5 ]
Yamamoto, Naoki [6 ,7 ]
Toi, Masakazu [1 ]
机构：
[1] Kyoto Univ, Dept Breast Surg, Grad Sch Med, Sakyo Ku, Kyoto 6068507, Japan
[2] Biotherapy Inst Japan, Tokyo, Japan
[3] Tokyo Clin Marunouchi Oazo, Tokyo, Japan
[4] NYU, Med Ctr, Dept Pathol, New York, NY 10016 USA
[5] Komagome Hosp, Dept Surg, Tokyo Metropolitan Canc & Infect Dis Ctr, Tokyo, Japan
[6] Tokyo Med & Dent Univ, Dept Mol Virol, Tokyo, Japan
[7] Natl Inst Infect Dis, Tokyo, Japan
来源：
BREAST CANCER | 2011年 / 18卷 / 01期
关键词：
Breast cancer; Metastasis; Natural killer cell; Chemotherapy; Trastuzumab; NATURAL-KILLER-CELLS; THYMIDINE PHOSPHORYLASE; TRASTUZUMAB RESISTANCE; ADJUVANT CHEMOTHERAPY; ACTIVATION; IMMUNOTHERAPY; CYTOTOXICITY; CAPECITABINE; INDUCTION; ANTIBODY;
D O I：
10.1007/s12282-010-0198-5
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A suggestive case of metastatic disease from breast cancer is reported. The HER-2-positive tumor was refractory to several agents, including anti-HER-2 therapy, trastuzumab, and lapatinib. After re-induction of trastuzumab in combination with activated natural killer (NK) cell injection therapy, tumor markers decreased, and finally a synergistic effect of taxane and capecitabine led to treatment response. This case suggests that multidisciplinary therapy including an immunological approach might be a breakthrough in the treatment of refractory disease.
引用
收藏
页码：64 / 67
页数：4
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