The two faces of the Integrated Stress Response in cancer progression and therapeutic strategies

被引：23

作者：

Licari, Eugenia ^{[1
]}

Sanchez-del-Campo, Luis ^{[2
]}

Falletta, Paola ^{[3
]}

机构：

[1] Univ Vita Salute San Raffaele, Milan, Italy

[2] Univ Murcia, Sch Biol, Dept Biochem & Mol Biol A, IMIB, Murcia 30100, Spain

[3] IRCCS Osped San Raffaele, Expt Imaging Ctr, Milan, Italy

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2021年 / 139卷

关键词：

Integrated Stress Response; eIF2; alpha; Adaptive/maladaptive; Translation reprogramming; ISR activators; ISR inhibitors; Cancer; UNFOLDED PROTEIN RESPONSE; INTERNAL RIBOSOME ENTRY; ENDOPLASMIC-RETICULUM STRESS; TO-MESENCHYMAL TRANSITION; INDUCED UP-REGULATION; TRANSLATION INITIATION; MALIGNANT-TRANSFORMATION; TRANSCRIPTION FACTOR; GENE-EXPRESSION; ATF4;

D O I：

10.1016/j.biocel.2021.106059

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In recent years considerable progress has been made in identifying the impact of mRNA translation in tumour progression. Cancer cells hijack the pre-existing translation machinery to thrive under the adverse conditions originating from intrinsic oncogenic programs, that increase their energetic demand, and from the hostile microenvironment. A key translation program frequently dysregulated in cancer is the Integrated Stress Response, that reprograms translation by attenuating global protein synthesis to decrease metabolic demand while increasing translation of specific mRNAs that support survival, migration, immune escape. In this review we provide an overview of the Integrated Stress Response, emphasise its dual role during tumorigenesis and cancer progression, and highlight the therapeutic strategies available to target it.

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页数：8

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