Cell fate decisions in early blood vessel formation

被引:53
作者
Ema, M
Rossant, J
机构
[1] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada
[2] Univ Toronto, Mt Sinai Hosp, Dept Mol & Med Genet, Toronto, ON M5G 1X5, Canada
[3] Univ Tsukuba, Inst Basic Med Sci, Dept Anat & Embryol, Tsukuba, Ibaraki 3058575, Japan
关键词
D O I
10.1016/S1050-1738(03)00105-1
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The close spatial relationship between endothelial and hematopoietic cells at different stages of development has led to the concept of a common progenitor, the hemangioblast. The vascular endothelial growth factor receptor, Flk1 or KDR, is a common marker of all cells-whether embryonic or adult-that have putative hemangioblast properties. In this article, a model is proposed in which Flk1 marks a common mesodermal precursor that segregates successive subsets of Flk1-expressing or Flk1-nonexpressing cells whose fate is determined by coexpression of lineage-specific transcription factors. Cells that retain Flkl activity have endothelial potential, cells that also activate downstream transcription factors such as Tall and Runx1 gain primitive or definitive hematopoietic activity, and cells that lose Flkl expression but gain expression of other transcription factors become smooth muscle or other cell types. (C) 2003, Elsevier Inc.
引用
收藏
页码:254 / 259
页数:6
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