Comparison of Ferric Sodium EDTA in Combination with Vitamin C, Folic Acid, Copper Gluconate, Zinc Gluconate, and Selenomethionine as Therapeutic Option for Chronic Kidney Disease Patients with Improvement in Inflammatory Status

被引：8

作者：

Giliberti, Antonella ^{[1
]}

Curcio, Annalisa ^{[2
]}

Marchitto, Nicola ^{[3
]}

Di Lullo, Luca ^{[4
]}

Paolozzi, Fulvia ^{[5
]}

Nano, Fabiana ^{[2
]}

Pironti, Michele ^{[2
]}

Raimondi, Gianfranco ^{[6
]}

机构：

[1] Santa Maria Grazie Hosp Pozzuoli, Dept Nephrol & Dialysis, I-80078 Naples, Italy

[2] Aqma Italia SpA, Med Dept, I-80138 Naples, Italy

[3] San Giovanni Dio Hosp, Dept Internal Med, I-04022 Fondi, Italy

[4] L Parodi Delfino Hosp, Dept Nephrol & Dialysis, I-00034 Colleferro, Italy

[5] Pellegrini Hosp, Dept Pharm, I-80134 Naples, Italy

[6] Sapienza Univ Rome, Fac Internal Med, Dept Medicosurg Sci & Biotechnol, I-04100 Latina, Italy

来源：

NUTRIENTS | 2022年 / 14卷 / 10期

关键词：

chronic kidney disease; iron deficiency anemia; ferric sodium EDTA; ferritin; C-reactive protein; hepcidin; inflammation; FORTIFIED SOY-SAUCE; IRON-DEFICIENCY; FISH SAUCE; NAFEEDTA; ANEMIA; CHILDREN; WOMEN; METAANALYSIS; ABSORPTION; CKD;

D O I：

10.3390/nu14102116

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Anemia is one of the most frequent and earliest complications of chronic kidney disease (CKD), which impacts a patient's quality of life and increases the risk of adverse clinical outcomes. Patients' inflammatory status is strictly related to the occurrence of functional iron deficiency anemia (IDA) because this causes an increase in hepcidin levels with the consequent inhibition of iron absorption and release from cellular stores into blood circulation. The aim of this study was to evaluate the use of the new oral formulation based on ferric sodium EDTA in combination with vitamin C, folic acid, copper gluconate, zinc gluconate, and selenomethionine (Ferachel Forte (R)) in patients with moderate CKD and functional IDA, analyzing the inflammatory status in addition to iron blood parameters, in comparison with oral ferrous sulfate and liposomal iron therapies. Sixty-two elderly patients were randomly allocated to one of the following oral treatments for 6 months: ferrous sulfate (Group 1; N = 20), ferric sodium EDTA in combination (Group 2; N = 22), and ferric liposomal formulation (Group 3; N = 20). The evaluated parameters included iron profile parameters of hemoglobin (Hb), sideremia, ferritin, transferrin saturation, C-reactive protein (CRP), and hepcidin. The results showed that in Group 1, there were no improvements. In Group 2, there were statistically significant (p < 0.001) improvements in all evaluated parameters. Finally, in Group 3, there were significant improvements in all evaluated parameters except for hepcidin, which was less than that of Group 2 patients. In conclusion, the findings showed the superior efficacy of the formulation based on ferric sodium EDTA over the other oral iron sources, and that this formulation can contribute to reducing the systemic inflammatory status in patients with CKD.

引用

页数：9

共 36 条

[1] Scientific Opinion on the use of ferric sodium EDTA as a source of iron added for nutritional purposes to foods for the general population (including food supplements) and to foods for particular nutritional uses EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS)
Aguilar, F.
Charrondiere, U. R.
Dusemund, B.
Galtier, P.
Gilbert, J.
Gott, D. M.
Grilli, S.
Guertler, R.
Koenig, J.
Lambr, C.
Larsen, J-C.
Leblanc, J-C.
Mortensen, A.
Parent-Massin, D.
Pratt, I.
Rietjens, I. M. C. M.
Stankovic, I.
Tobback, P.
Verguieva, T.
Woutersen, R. A.
[J]. EFSA JOURNAL, 2010, 8 (01)
[2] [Anonymous], 2007, JOINT FAO WHO EXP CO
[3] Prevalence, correlates and outcomes of absolute and functional iron deficiency anemia in nondialysis-dependent chronic kidney disease
Awan, Ahmed A.
Walther, Carl P.
Richardson, Peter A.
Shah, Maulin
Winkelmayer, Wolfgang C.
Navaneethan, Sankar D.
[J]. NEPHROLOGY DIALYSIS TRANSPLANTATION, 2021, 36 (01) : 129 - 136
[4] Molecular Mechanisms of Hepcidin Regulation: Implications for the Anemia of CKD
Babitt, Jodie L.
Lin, Herbert Y.
[J]. AMERICAN JOURNAL OF KIDNEY DISEASES, 2010, 55 (04) : 726 - 741
[5] Anemia of Inflammation with An Emphasis on Chronic Kidney Disease
Begum, Sajidah
Latunde-Dada, Gladys O.
[J]. NUTRIENTS, 2019, 11 (10)
[6] Iron-Deficiency Anemia
Camaschella, Clara
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2015, 372 (19) : 1832 - 1843
[7] Cignini Pietro, 2015, J Prenat Med, V9, P1, DOI 10.11138/jpm/2015.9.1.001
[8] Curcio A., 2018, J BLOOD LYMPH, V8, P224, DOI [10.4172/2165-7831.1000224, DOI 10.4172/2165-7831.1000224]
[9] Dary O., 2006, Guidelines on food fortification with micronutrients
[10] Point-of-use fortification of foods with micronutrient powders containing iron in children of preschool and school-age
De-Regil, Luz Maria
Jefferds, Maria Elena D.
Pena-Rosas, Juan Pablo
[J]. COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2017, (11):

← 1 2 3 4 →