Torsades de Pointes Induced by the Concomitant Use of Ivabradine and Azithromycin: An Unexpected Dangerous Interaction

被引：32
作者：
Cocco, Giuseppe [1 ]
Jerie, Paul [1 ]
机构：
[1] Cardiol Off, CH-4310 Rheinfelden, Switzerland
来源：
CARDIOVASCULAR TOXICOLOGY | 2015年 / 15卷 / 01期
关键词：
Pharmacodynamic toxicity; Torsades de pointes; Azithromycin; Ivabradine; Proarrhythmic effect; PHARMACOKINETIC INTERACTION; HEALTHY-VOLUNTEERS; HEART-RATE;
D O I：
10.1007/s12012-014-9274-y
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A 68-year-old man had a cardiac syncope. He was known to have a long QT-interval and was treated with ivabradine for paroxysmal sinusal tachycardia. In the last 5 days, azithromycin had been prescribed for sinusitis. An electrocardiogram showed torsades de pointes (TdP). Azithromycin is known to prolong the QT-interval. Ivabradine does not affect the QT-interval but has a conditional risk of TdP when taken with other drugs that block its metabolic breakdown. This case presents the specific problem of a patient with long QT who received two medications, which may interact and prolong the QT.
引用
收藏
页码：104 / 106
页数：3
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