Endometrial cancer risk factors among Lynch syndrome women: a retrospective cohort study

被引：15

作者：

Staff, Synnove ^{[1
,2
]}

Aaltonen, Mari ^{[1
]}

Huhtala, Heini ^{[3
]}

Pylvanainen, Kirsi ^{[4
]}

Mecklin, Jukka-Pekka ^{[5
,6
]}

Maenpaa, Johanna ^{[1
,7
]}

机构：

[1] Tampere Univ Hosp, Dept Obstet & Gynecol, Tampere, Finland

[2] Univ Tampere, Canc Biol Lab, BioMediTech, Tampere, Finland

[3] Univ Tampere, Sch Hlth Sci, Tampere, Finland

[4] Jyvaskyla Cent Hosp, Dept Educ & Res, Jyvaskyla, Finland

[5] Jyvaskyla Cent Hosp, Dept Surg, Jyvaskyla, Finland

[6] Univ Eastern Finland, Jyvaskyla, Finland

[7] Univ Tampere, Sch Med, Tampere, Finland

来源：

BRITISH JOURNAL OF CANCER | 2016年 / 115卷 / 03期

关键词：

Lynch syndrome; endometrial cancer; risk; lifestyle; medical history; reproductive history; BODY-MASS INDEX; MISMATCH REPAIR; PROTEIN EXPRESSION; METAANALYSIS;

D O I：

10.1038/bjc.2016.193

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Lynch syndrome (LS) is associated with a significant lifetime risk of endometrial cancer (EC). There are limited data on factors modifying the EC risk in LS patients. Methods: The study cohort included 136 LS mutation-positive women. Exposure data were collected by postal questionnaires. Cox regression model was used to estimate the associations between lifestyle, hormonal, reproductive and medical factors and the risk of EC. Results: Increased EC risk was associated with type II diabetes and hypercholesterolaemia in univariable (HR 3.21, (95% CI 1.34-7.78), P = 0.009 and HR 2.08, (95% CI 1.11-3.90), P = 0.02; respectively) and with diabetes and duration of hormone replacement therapy (HRT) in multivariable analysis (HR 4.18 (95% CI 1.52-11.52), P = 0.006 and HR 1.07 (95% CI 1.02-1.13), P = 0.010; respectively). Conclusions: Prevention of diabetes and avoiding long-duration HRT are potential targets for reduction of EC risk in women with LS.

引用

页码：375 / 381

页数：7

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