Effects of fine particulate matter (PM2.5) on ovarian function and embryo quality in mice

被引：44

作者：

Liao, Bao-Qiong ^{[1
,2
,3
,4
]}

Liu, Chao-Bin ^{[5
]}

Xie, Shu-Juan ^{[3
,4
]}

Liu, Yu ^{[4
,6
]}

Deng, Ya-Bin ^{[1
]}

He, Shu-Wen ^{[4
]}

Fu, Xian-Pei ^{[4
]}

Fu, Bin-Bin ^{[4
]}

Wang, Ya-Long ^{[4
]}

Chen, Ming-Huang ^{[4
]}

Lin, Yan-Hong ^{[4
]}

Li, Fei-Ping ^{[4
]}

Xie, Xi ^{[5
]}

Hong, Xin-Ru ^{[3
]}

Wang, Hai-Long ^{[1
,4
,7
]}

机构：

[1] Xiamen Univ, Canc Res Ctr, Sch Med, Xiamen 361102, Fujian, Peoples R China

[2] Ganzhou Maternal & Child Hlth Hosp, Dept Reprod & Genet, Ganzhou 341000, Jiangxi, Peoples R China

[3] Xiamen Univ, Dongfang Affiliated Hosp, Fujian Med Univ, Fuzhou Clin Med Coll,Joint Logist Team,900 Hosp,D, Fuzhou 350025, Fujian, Peoples R China

[4] Xiamen Univ, Sch Med, Organ Transplantat Inst, Xiamen 361102, Fujian, Peoples R China

[5] Fujian Med Univ, Fujian Prov Matern & Childrens Hosp, Dept Gynecol 4, Affiliated Hosp, Fuzhou 350001, Fujian, Peoples R China

[6] Guangxi Univ, Med Coll, Nanning 530004, Guangxi, Peoples R China

[7] Xiamen Univ, Sch Med, Dept Basic Med, Xiamen 361102, Fujian, Peoples R China

来源：

ENVIRONMENT INTERNATIONAL | 2020年 / 135卷

基金：

中国国家自然科学基金;

关键词：

PM2.5; Ovary; Embryo; Oocyte; Mice; IN-VITRO FERTILIZATION; SHORT-TERM IMPACT; AIR-POLLUTION; PARTICLES; MORTALITY; APOPTOSIS; EXPOSURE; OOCYTES; SYSTEM; GROWTH;

D O I：

10.1016/j.envint.2019.105338

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Fine particulate matter (PM2.5) has an adverse effect on reproductive function, in particular causing reduced male reproductive function, but relatively few studies have directly targeted its effects on female reproduction. To investigate the effects of PM(2.5 )exposure on female reproduction, we exposed female mice to PM2.5 by intratracheal instillation for 28 days, and evaluated apoptosis of ovarian granulosa cells and oocytes and the quality embryos after insemination. Our results showed increased numbers of apoptotic granulosa cells and oocytes after exposure to elevated concentrations of PM2.5, which had adverse effects on female fertility via compromising embryo development and quality. We conclude that PM2.5 induced apoptosis of ovarian granulosa cells and oocytes leading to disrupted embryo development and female fertility in mice.

引用

页数：9

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