Effects of fine particulate matter (PM2.5) on ovarian function and embryo quality in mice

被引：44

作者：

Liao, Bao-Qiong ^{[1
,2
,3
,4
]}

Liu, Chao-Bin ^{[5
]}

Xie, Shu-Juan ^{[3
,4
]}

Liu, Yu ^{[4
,6
]}

Deng, Ya-Bin ^{[1
]}

He, Shu-Wen ^{[4
]}

Fu, Xian-Pei ^{[4
]}

Fu, Bin-Bin ^{[4
]}

Wang, Ya-Long ^{[4
]}

Chen, Ming-Huang ^{[4
]}

Lin, Yan-Hong ^{[4
]}

Li, Fei-Ping ^{[4
]}

Xie, Xi ^{[5
]}

Hong, Xin-Ru ^{[3
]}

Wang, Hai-Long ^{[1
,4
,7
]}

机构：

[1] Xiamen Univ, Canc Res Ctr, Sch Med, Xiamen 361102, Fujian, Peoples R China

[2] Ganzhou Maternal & Child Hlth Hosp, Dept Reprod & Genet, Ganzhou 341000, Jiangxi, Peoples R China

[3] Xiamen Univ, Dongfang Affiliated Hosp, Fujian Med Univ, Fuzhou Clin Med Coll,Joint Logist Team,900 Hosp,D, Fuzhou 350025, Fujian, Peoples R China

[4] Xiamen Univ, Sch Med, Organ Transplantat Inst, Xiamen 361102, Fujian, Peoples R China

[5] Fujian Med Univ, Fujian Prov Matern & Childrens Hosp, Dept Gynecol 4, Affiliated Hosp, Fuzhou 350001, Fujian, Peoples R China

[6] Guangxi Univ, Med Coll, Nanning 530004, Guangxi, Peoples R China

[7] Xiamen Univ, Sch Med, Dept Basic Med, Xiamen 361102, Fujian, Peoples R China

来源：

ENVIRONMENT INTERNATIONAL | 2020年 / 135卷

基金：

中国国家自然科学基金;

关键词：

PM2.5; Ovary; Embryo; Oocyte; Mice; IN-VITRO FERTILIZATION; SHORT-TERM IMPACT; AIR-POLLUTION; PARTICLES; MORTALITY; APOPTOSIS; EXPOSURE; OOCYTES; SYSTEM; GROWTH;

D O I：

10.1016/j.envint.2019.105338

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Fine particulate matter (PM2.5) has an adverse effect on reproductive function, in particular causing reduced male reproductive function, but relatively few studies have directly targeted its effects on female reproduction. To investigate the effects of PM(2.5 )exposure on female reproduction, we exposed female mice to PM2.5 by intratracheal instillation for 28 days, and evaluated apoptosis of ovarian granulosa cells and oocytes and the quality embryos after insemination. Our results showed increased numbers of apoptotic granulosa cells and oocytes after exposure to elevated concentrations of PM2.5, which had adverse effects on female fertility via compromising embryo development and quality. We conclude that PM2.5 induced apoptosis of ovarian granulosa cells and oocytes leading to disrupted embryo development and female fertility in mice.

引用

页数：9

共 50 条

[21] Fine Particulate Matter (PM2.5) and the Risk of Stroke in the REGARDS Cohort
McClure, Leslie A.
Loop, Matthew S.
Crosson, William L.
Kleindorfer, Dawn O.
Kissela, Brett M.
Al-Hamdan, Mohammad Z.
STROKE, 2013, 44 (02)
[22] Exposure to fine particulate matter (PM2.5) and pediatric rheumatic diseases
Wang, Chi-Min
Jung, Chau-Ren
Chen, Wei-Ting
Hwang, Bing-Fang
ENVIRONMENT INTERNATIONAL, 2020, 138
[23] The characteristics and drivers of fine particulate matter (PM2.5) distribution in China
Wang, Shaojian
Zhou, Chunshan
Wang, Zhenbo
Feng, Kuishuang
Hubacek, Klaus
JOURNAL OF CLEANER PRODUCTION, 2017, 142 : 1800 - 1809
[24] Fine Particulate Matter (PM2.5) and the Risk of Stroke in the REGARDS Cohort
McClure, Leslie A.
Loop, Matthew S.
Crosson, William
Kleindorfer, Dawn
Kissela, Brett
Al-Hamdan, Mohammad
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 2017, 26 (08): : 1739 - 1744
[25] The health economic loss of fine particulate matter (PM2.5) in Beijing
Li, Li
Lei, Yalin
Wu, Sanmang
Chen, Jiabin
Yan, Dan
JOURNAL OF CLEANER PRODUCTION, 2017, 161 : 1153 - 1161
[26] Growing Urbanization and the Impact on Fine Particulate Matter (PM2.5) Dynamics
Han, Lijian
Zhou, Weiqi
Li, Weifeng
SUSTAINABILITY, 2018, 10 (06):
[27] Characterization of air quality and sources of fine particulate matter (PM2.5) in the City of Calgary, Canada
Bari, Md Aynul
Kindzierski, Warren B.
ATMOSPHERIC POLLUTION RESEARCH, 2018, 9 (03) : 534 - 543
[28] Exploring the adverse effect of fine particulate matter (PM2.5) on wildland firefighters' pulmonary function and DNA damage
Panumasvivat, Jinjuta
Sapbamrer, Ratana
Sittitoon, Nalin
Khacha-ananda, Supakit
Kiratipaisarl, Wuttipat
Sirikul, Wachiranun
Insian, Wittawat
Assavanopakun, Pheerasak
SCIENTIFIC REPORTS, 2024, 14 (01)
[29] Effect of Fine Particulate Matter (PM2.5) on Rat Placenta Pathology and Perinatal Outcomes
Liu, Yi
Wang, Ledan
Wang, Fang
Li, Changzhong
MEDICAL SCIENCE MONITOR, 2016, 22 : 3274 - 3280
[30] Cluster analysis of fine particulate matter (PM2.5) emissions and its bioreactivity in the vicinity of a petrochemical complex
Chuang, Hsiao-Chi
Shie, Ruei-Hao
Chio, Chia-Pin
Yuan, Tzu-Hsuen
Lee, Jui-Huan
Chan, Chang-Chuan
ENVIRONMENTAL POLLUTION, 2018, 236 : 591 - 597

← 1 2 3 4 5 →