Effects of fine particulate matter (PM2.5) on ovarian function and embryo quality in mice

被引：44

作者：

Liao, Bao-Qiong ^{[1
,2
,3
,4
]}

Liu, Chao-Bin ^{[5
]}

Xie, Shu-Juan ^{[3
,4
]}

Liu, Yu ^{[4
,6
]}

Deng, Ya-Bin ^{[1
]}

He, Shu-Wen ^{[4
]}

Fu, Xian-Pei ^{[4
]}

Fu, Bin-Bin ^{[4
]}

Wang, Ya-Long ^{[4
]}

Chen, Ming-Huang ^{[4
]}

Lin, Yan-Hong ^{[4
]}

Li, Fei-Ping ^{[4
]}

Xie, Xi ^{[5
]}

Hong, Xin-Ru ^{[3
]}

Wang, Hai-Long ^{[1
,4
,7
]}

机构：

[1] Xiamen Univ, Canc Res Ctr, Sch Med, Xiamen 361102, Fujian, Peoples R China

[2] Ganzhou Maternal & Child Hlth Hosp, Dept Reprod & Genet, Ganzhou 341000, Jiangxi, Peoples R China

[3] Xiamen Univ, Dongfang Affiliated Hosp, Fujian Med Univ, Fuzhou Clin Med Coll,Joint Logist Team,900 Hosp,D, Fuzhou 350025, Fujian, Peoples R China

[4] Xiamen Univ, Sch Med, Organ Transplantat Inst, Xiamen 361102, Fujian, Peoples R China

[5] Fujian Med Univ, Fujian Prov Matern & Childrens Hosp, Dept Gynecol 4, Affiliated Hosp, Fuzhou 350001, Fujian, Peoples R China

[6] Guangxi Univ, Med Coll, Nanning 530004, Guangxi, Peoples R China

[7] Xiamen Univ, Sch Med, Dept Basic Med, Xiamen 361102, Fujian, Peoples R China

来源：

ENVIRONMENT INTERNATIONAL | 2020年 / 135卷

基金：

中国国家自然科学基金;

关键词：

PM2.5; Ovary; Embryo; Oocyte; Mice; IN-VITRO FERTILIZATION; SHORT-TERM IMPACT; AIR-POLLUTION; PARTICLES; MORTALITY; APOPTOSIS; EXPOSURE; OOCYTES; SYSTEM; GROWTH;

D O I：

10.1016/j.envint.2019.105338

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Fine particulate matter (PM2.5) has an adverse effect on reproductive function, in particular causing reduced male reproductive function, but relatively few studies have directly targeted its effects on female reproduction. To investigate the effects of PM(2.5 )exposure on female reproduction, we exposed female mice to PM2.5 by intratracheal instillation for 28 days, and evaluated apoptosis of ovarian granulosa cells and oocytes and the quality embryos after insemination. Our results showed increased numbers of apoptotic granulosa cells and oocytes after exposure to elevated concentrations of PM2.5, which had adverse effects on female fertility via compromising embryo development and quality. We conclude that PM2.5 induced apoptosis of ovarian granulosa cells and oocytes leading to disrupted embryo development and female fertility in mice.

引用

页数：9

共 50 条

[1] Effects of ß-Adrenoceptor Subtypes on Cardiac Function in Myocardial Infarction Rats Exposed to Fine Particulate Matter (PM2.5)
Gao, Yuping
Lv, Jiyuan
Lin, Yuanyuan
Li, Xuewen
Wang, Lixia
Yin, Yanping
Liu, Yan
BIOMED RESEARCH INTERNATIONAL, 2014, 2014
[2] The relationship between fine particulate matter (PM2.5) and schizophrenia severity
Eguchi, Rika
Onozuka, Daisuke
Ikeda, Kouji
Kuroda, Kenji
Ieiri, Ichiro
Hagihara, Akihito
INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH, 2018, 91 (05) : 613 - 622
[3] Effects of Fine Particulate Matter (PM2.5) on Systemic Oxidative Stress and Cardiac Function in ApoE-/- Mice
Pei, Yiling
Jiang, Rongfang
Zou, Yunzeng
Wang, Yu
Zhang, Suhui
Wang, Guanghe
Zhao, Jinzhuo
Song, Weimin
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2016, 13 (05)
[4] Effects of the Particulate Matter2.5 (PM2.5) on Lipoprotein Metabolism, Uptake and Degradation, and Embryo Toxicity
Kim, Jae-Yong
Lee, Eun-Young
Choi, Inho
Kim, Jihoe
Cho, Kyung-Hyun
MOLECULES AND CELLS, 2015, 38 (12) : 1096 - 1104
[5] HORMESIS FOR FINE PARTICULATE MATTER (PM 2.5)
Cox, Louis Anthony , Jr.
DOSE-RESPONSE, 2012, 10 (02): : 209 - 218
[6] In vivo and in vitro inflammatory responses to fine particulate matter (PM2.5) from China and California
Yuan, Wanjun
Fulgar, Ciara C.
Sun, Xiaolin
Vogel, Christoph F. A.
Wu, Ching-Wen
Zhang, Qi
Bein, Keith J.
Young, Dominique E.
Li, Wei
Wei, Haiying
Pinkerto, Kent E.
TOXICOLOGY LETTERS, 2020, 328 : 52 - 60
[7] Effects of ozone and fine particulate matter (PM2.5) on rat system inflammation and cardiac function
Wang, Guanghe
Jiang, Rongfang
Zhao, Zhuohui
Song, Weimin
TOXICOLOGY LETTERS, 2013, 217 (01) : 23 - 33
[8] Exposure to fine particulate matter (PM2.5) and noise at bus stops in Chennai, India
Mahesh, Srinath
JOURNAL OF TRANSPORT & HEALTH, 2021, 22
[9] The effect of fine particulate matter (PM2.5) pollution on health inequality: an intergenerational perspective
Yan, Dan
Ji, Honglu
Fu, Hong
Jiang, Jingjing
Su, Bin
Ye, Bin
ENVIRONMENTAL GEOCHEMISTRY AND HEALTH, 2024, 46 (06)
[10] Fine particulate matter (PM2.5) in China at a city level
Zhang, Yan-Lin
Cao, Fang
SCIENTIFIC REPORTS, 2015, 5

← 1 2 3 4 5 →