Applications of Spherical Nucleic Acid Nanoparticles as Delivery Systems

被引：66

作者：

Mokhtarzadeh, Ahad ^{[1
,2
]}

Vahidnezhad, Hassan ^{[3
,4
]}

Youssefian, Leila ^{[3
,4
,5
]}

Mosafer, Jafar ^{[6
]}

Baradaran, Behzad ^{[1
]}

Uitto, Jouni ^{[3
,4
]}

机构：

[1] Tabriz Univ Med Sci, Immunol Res Ctr, Tabriz, Iran

[2] Higher Educ Inst Rab Rashid, Dept Biotechnol, Tabriz, Iran

[3] Thomas Jefferson Univ, Sidney Kimmel Med Coll, Dept Dermatol & Cutaneous Biol, Philadelphia, PA 19107 USA

[4] Thomas Jefferson Univ, Jefferson Inst Mol Med, Philadelphia, PA 19107 USA

[5] Thomas Jefferson Univ, Genet Genom & Canc Biol PhD Program, Philadelphia, PA 19107 USA

[6] Torbat Heydariyeh Univ Med Sci, Res Ctr Adv Technol Med, Torbat Heydariyeh, Iran

来源：

TRENDS IN MOLECULAR MEDICINE | 2019年 / 25卷 / 12期

关键词：

CELLULAR UPTAKE; PROTEIN CORONA; MICRORNA; OLIGONUCLEOTIDES; CONJUGATION; ACTIVATION; PEGYLATION; NANOFLARES; STABILITY; RESPONSES;

D O I：

10.1016/j.molmed.2019.08.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Spherical nucleic acids (SNAs) are nanostructures consisting of highly oriented, dense layers of oligonucleotides arranged in a spherical 3D geometry. Owing to their unique properties and function, SNAs occupy a material space distinct from 'DNA nanotechnology' and DNA origami. Over the past two decades SNAs have revolutionized gene regulation, drug delivery, gene therapy, and molecular diagnostics, and show promise for both antisense and RNAi therapy. We focus here on recent advances in the synthesis and application of SNAs in gene and drug delivery, diagnostics, and immunomodulation, as well as on the utility of nanoflares as intracellular mRNA detection systems.

引用

收藏

页码：1066 / 1079

页数：14

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