Dietary restriction and lifespan: Lessons from invertebrate models

被引:222
作者
Kapahi, Pankaj [1 ]
Kaeberlein, Matt [2 ]
Hansen, Malene [3 ]
机构
[1] Buck Inst Res Aging, Novato, CA USA
[2] Univ Washington, Dept Pathol, Seattle, WA 98195 USA
[3] Sanford Burnham Prebys Med Discovery Inst, La Jolla, CA 92037 USA
关键词
Yeast; Worms; Flies; Mitochondrial respiration; Sirtuins; Autophagy; Metabolism; CHRONOLOGICALLY AGING YEAST; POSITION-EFFECT VARIEGATION; SACCHAROMYCES-CEREVISIAE; CAENORHABDITIS-ELEGANS; CALORIE RESTRICTION; DROSOPHILA-MELANOGASTER; C-ELEGANS; STRESS RESISTANCE; INDUCED LONGEVITY; GENE-EXPRESSION;
D O I
10.1016/j.arr.2016.12.005
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Dietary restriction (DR) is the most robust environmental manipulation known to increase active and healthy lifespan in many species. Despite differences in the protocols and the way DR is carried out in different organisms, conserved relationships are emerging among multiple species. Elegant studies from numerous model organisms are further defining the importance of various nutrient-signaling pathways including mTOR (mechanistic target of rapamycin), insulin/IGF-1-like signaling and sirtuins in mediating the effects of DR. We here review current advances in our understanding of the molecular mechanisms altered by DR to promote lifespan in three major invertebrate models, the budding yeast Saccharomyces cerevisiae, the nematode Caenorhabditis elegans, and the fruit fly Drosophila melanogaster. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码:3 / 14
页数:12
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