Highly efficient synthesis of chiral aromatic ketones via Rh-catalyzed asymmetric hydrogenation of β,β-disubstituted enones

被引：22

作者：

Zhang, Tao ^{[1
]}

Jiang, Jun ^{[2
]}

Yao, Lin ^{[3
]}

Geng, Huiling ^{[1
]}

Zhang, Xumu ^{[4
]}

机构：

[1] Northwest A&F Univ, Sch Pharm & Chem, Yangling 712100, Shaanxi, Peoples R China

[2] Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Hubei, Peoples R China

[3] Fourth Mil Med Univ, Sch Chem & Pharm, Xian 710032, Shaanxi, Peoples R China

[4] South Univ Sci & Technol, Dept Chem, Guangzhou 518055, Guangdong, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 66期

基金：

中国国家自然科学基金;

关键词：

CONJUGATE ADDITION; ALPHA; BETA-UNSATURATED KETONES; THIOUREA; LIGANDS; 1,4-ADDITION; DIETHYLZINC; REDUCTION; COMPLEXES;

D O I：

10.1039/c7cc04045h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A succinct and efficient protocol was developed for the synthesis of chiral aromatic ketones via asymmetric hydrogenation of beta,beta-disubstituted enones with rhodium catalysts based on chiral bisphosphine thiourea ligands. A series of substrates (17 examples) was smoothly catalyzed to afford the corresponding chiral aromatic ketones in high conversions (>99%) with excellent enantioselectivities (up to 96% ee).

引用

页码：9258 / 9261

页数：4

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