The Patho-Neurophysiological Basis and Treatment of Focal Laryngeal Dystonia: A Narrative Review and Two Case Reports Applying TMS over the Laryngeal Motor Cortex

被引：1

作者：

Vidakovic, Maja Rogic ^{[1
]}

Gunjaca, Ivana ^{[2
]}

Bukic, Josipa ^{[3
]}

Kosta, Vana ^{[4
]}

Soda, Josko ^{[5
]}

Konstantinovic, Ivan ^{[6
]}

Boskovic, Braco ^{[7
]}

Bilic, Irena ^{[7
]}

Muzinic, Nikolina Rezic ^{[8
]}

机构：

[1] Univ Split, Lab Human & Expt Neurophysiol, Dept Neurosci, Sch Med, Split 21000, Croatia

[2] Univ Split, Dept Med Biol, Sch Med, Split 21000, Croatia

[3] Univ Split, Dept Pharm, Sch Med, Split 21000, Croatia

[4] Univ Hosp Split, Dept Neurol, Split 21000, Croatia

[5] Univ Split, Signal Proc Anal & Adv Diagnost Res & Educ Lab SP, Fac Maritime Studies, Split 21000, Croatia

[6] Univ Hosp Split, Dept Neurosurg, Split 21000, Croatia

[7] Univ Hosp Split, Dept Otorhinolaryngol, Split 21000, Croatia

[8] Univ Split, Dept Med Chem & Biochem, Sch Med, Split 21000, Croatia

来源：

JOURNAL OF CLINICAL MEDICINE | 2022年 / 11卷 / 12期

关键词：

spasmodic dysphonia; laryngeal dystonia; dystonia; focal dystonia; focal laryngeal dystonia; TRANSCRANIAL MAGNETIC STIMULATION; BOTULINUM TOXIN MANAGEMENT; SPASMODIC DYSPHONIA; AFFERENT INHIBITION; 12-YEAR EXPERIENCE; EVOKED-POTENTIALS; MUTATIONS; DYT16; REPRESENTATION; ABNORMALITIES;

D O I：

10.3390/jcm11123453

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Focal laryngeal dystonia (LD) is a rare, idiopathic disease affecting the laryngeal musculature with an unknown cause and clinically presented as adductor LD or rarely as abductor LD. The most effective treatment options include the injection of botulinum toxin (BoNT) into the affected laryngeal muscle. The aim of this narrative review is to summarize the patho-neuro-physiological and genetic background of LD, as well as the standard recommended therapy (BoNT) and pharmacological treatment options, and to discuss possible treatment perspectives using neuro-modulation techniques such as repetitive transcranial magnetic stimulation (rTMS) and vibrotactile stimulation. The review will present two LD cases, patients with adductor and abductor LD, standard diagnostic procedure, treatments and achievement, and the results of cortical excitability mapping the primary motor cortex for the representation of the laryngeal muscles in the assessment of corticospinal and corticobulbar excitability.

引用

页数：21