Mutagenic, antioxidant and wound healing properties of Aloe vera

被引：35

作者：

Oliveira Rodrigues, Luiza Lucy ^{[1
]}

Leal de Oliveira, Ana Carolina ^{[1
]}

Tabrez, Shams ^{[2
]}

Shakil, Shazi ^{[3
,4
,5
]}

Khan, Mohammad Imran ^{[6
]}

Asghar, Muhammad Nadeem ^{[7
]}

Matias, Bianca Dias ^{[1
]}

Alves da Silva Batista, Joysa Michelle ^{[1
]}

Rosal, Marinilva Modesto ^{[1
]}

Duarte Fulgencio de Lima, Marylia Maria ^{[1
]}

Ferreira Gomes, Savia Ribeiro ^{[1
]}

de Carvalho, Rodrigo Mendes ^{[8
]}

de Moraes, Germano Pinho ^{[9
]}

Oliveira Barros de Alencar, Marcus Vinicius ^{[10
]}

Islam, Muhammad Torequl ^{[11
,12
]}

de Carvalho Melo-Cavalcante, Ana Amelia ^{[10
]}

机构：

[1] NOVAFAPI, Grad Program, Fac Med, Teresina, PI, Brazil

[2] King Abdulaziz Univ, King Fahd Med Res Ctr, Jeddah, Saudi Arabia

[3] King Abdulaziz Univ, Ctr Innovat Personalized Med, Jeddah, Saudi Arabia

[4] King Abdulaziz Univ, Fac Appl Med Sci, Dept Med Lab Technol, Jeddah, Saudi Arabia

[5] King Abdulaziz Univ, Ctr Excellence Genom Med Res, Jeddah, Saudi Arabia

[6] King Abdulaziz Univ, Dept Biochem, Jeddah, Saudi Arabia

[7] Univ Quebec, Dept Med Biol, Trois Riveres, PQ, Canada

[8] NOVAFAPI, Fac Biochem, Grad Program, Teresina, PI, Brazil

[9] Univ Luterana Brasil, Postgrad Program Cellular Biol Appl Hlth PPGBioSa, Canoas, Brazil

[10] Univ Fed Piaui, Postgrad Program Pharmaceut Sci, Teresina, PI, Brazil

[11] Ton Duc Thang Univ, Dept Management Sci & Technol Dev, Ho Chi Minh City, Vietnam

[12] Ton Duc Thang Univ, Fac Pharm, Ho Chi Minh City, Vietnam

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2018年 / 227卷

关键词：

Aloe vera; Antioxidant; Cytotoxicity; Healing; Mutagenicity; MEDICINAL-PLANTS; OXIDATIVE STRESS; EXTRACT; GENOTOXICITY; DAMAGE; GENE; RATS;

D O I：

10.1016/j.jep.2018.08.034

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Ethnopharmacological relevance: Aloe vera is a widely used medicinal plant for its various biological activities. This study evaluate possible mutagenic and healing effects of the aqueous extract of A. vera (AEAV) in mice and its oxidant/antioxidant potential in different proficient and deficient Saccharomyces cerevisiae strains. Material and methods: The AEAV was topically treated on the wounded skin surface of male albino mice at doses of 10 and 50 mg/kg for seven successive days. The control group was similarly treated with 0.9% NaCl solution. For oxidative/anti-oxidative evaluation, both proficient and deficient strains of S. cerevisiae [cytoplasmic and mitochondrial superoxide dismutase mutant (SOD: Sod1 Delta and Sod2 Delta), cytoplasmic catalase mutant (CAT: Cat1 Delta)], two double defective mutants of Sod1 and Sod2 and Sod1 and Cat1 genes along with a wild-type strains were used. Results: The healing property of AEAV was observed at the dose of 50 mg/kg but at the same dose it showed mutagenic and cytotoxic effects in peripheral blood. AEAV did not produce the oxidizing effect, except in the mutated CAT strain at highest concentration (50 mg/kg). Conclusion: The high concentration of AEAV showed mutagenicity and cytotoxicity. Beside, the healing capacity is believed to be due to its anti-oxidative defense mechanism.

引用

页码：191 / 197

页数：7

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