Structural dynamics of eukaryotic chromosome evolution

被引：313
作者：
Eichler, EE [1 ]
Sankoff, D
机构：
[1] Case Western Reserve Univ, Sch Med, Ctr Human Genet, Dept Genet, Cleveland, OH 44106 USA
[2] Case Western Reserve Univ, Sch Med, Ctr Computat Genom, Cleveland, OH 44106 USA
[3] Univ Hosp Cleveland, Cleveland, OH 44106 USA
[4] Univ Ottawa, Dept Math & Stat, Ottawa, ON K1N 6N5, Canada
来源：
SCIENCE | 2003年 / 301卷 / 5634期
关键词：
D O I：
10.1126/science.1086132
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Large-scale genome sequencing is providing a comprehensive view of the complex evolutionary forces that have shaped the structure of eukaryotic chromosomes. Comparative sequence analyses reveal patterns of apparently random rearrangement interspersed with regions of extraordinarily rapid, localized genome evolution. Numerous subtle rearrangements near centromeres, telomeres, duplications, and interspersed repeats suggest hotspots for eukaryotic chromosome evolution. This localized chromosomal instability may play a role in rapidly evolving lineage-specific gene families and in fostering large-scale changes in gene order. Computational algorithms that take into account these dynamic forces along with traditional models of chromosomal rearrangement show promise for reconstructing the natural history of eukaryotic chromosomes.
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收藏
页码：793 / 797
页数：5
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