Therapeutic effect of mesenchymal stem cells in an animal model of Alzheimer's disease evaluated by β-amyloid positron emission tomography imaging

被引：19
作者：
Park, Bok-Nam [1 ]
Kim, Jang-Hee [2 ]
Lim, Tae Sung [3 ]
Park, So Hyun [2 ]
Kim, Tae-Gyu [2 ]
Yoon, Bok Seon [4 ]
Son, Keoung Sun [4 ]
Yoon, Joon-Kee [1 ]
An, Young-Sil [1 ]
机构：
[1] Ajou Univ, Sch Med, Dept Nucl Med & Mol Imaging, 206 World Cup Ro, Suwon 16499, Gyeonggi Do, South Korea
[2] Ajou Univ, Sch Med, Dept Pathol, Suwon, South Korea
[3] Ajou Univ, Sch Med, Dept Neurol, Suwon, South Korea
[4] Ajou Univ, Sch Med, Neurosci Grad Program, Biomed Sci, Suwon, South Korea
来源：
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY | 2020年 / 54卷 / 09期
基金：
新加坡国家研究基金会;
关键词：
F-18]Florbetaben; positron emission tomography; Alzheimer's disease; beta-amyloid; mesenchymal stem cells; MOUSE MODELS; IMPROVE COGNITION; TRANSGENIC MODEL; BRAIN; DEPOSITION; TRANSPLANTATION; MICE; CONTRIBUTE; DEMENTIA; PROMOTES;
D O I：
10.1177/0004867420917467
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Objective: We evaluated the effects of bone marrow-derived mesenchymal stem cells in a model of Alzheimer's disease using serial [F-18]Florbetaben positron emission tomography. Methods: 3xTg Alzheimer's disease mice were treated with intravenously injected bone marrow-derived mesenchymal stem cells, and animals without stem cell therapy were used as controls. Serial [F-18]Florbetaben positron emission tomography was performed after therapy. The standardized uptake value ratio was measured as the cortex standardized uptake value divided by the cerebellum standardized uptake value. Memory function and histological changes were observed using the Barnes maze test and beta-amyloid-reactive cells. Results: Standardized uptake value ratio decreased significantly from day 14 after stem cell administration in the bone marrow-derived mesenchymal stem cells-treated group (n = 28). In contrast, there was no change in the ratio in control mice (n = 25) at any time point. In addition, mice that received bone marrow-derived mesenchymal stem cell therapy also exhibited significantly better memory function and less beta-amyloid-immunopositive plaques compared to controls. Conclusion: The therapeutic effect of intravenously injected bone marrow-derived mesenchymal stem cells in a mouse model of Alzheimer's disease was confirmed by beta-amyloid positron emission tomography imaging, memory functional studies and histopathological evaluation.
引用
收藏
页码：883 / 891
页数：9
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