F7 and topotecan co-loaded thermosensitive liposome as a nano-drug delivery system for tumor hyperthermia

被引：28

作者：

Du, Chunyang ^{[1
]}

Li, Shuangshuang ^{[1
]}

Li, Yuan ^{[1
]}

Galons, Herve ^{[1
,2
]}

Guo, Na ^{[1
]}

Teng, Yuou ^{[1
]}

Zhang, Yongmin ^{[1
,2
]}

Li, Mingyuan ^{[1
]}

Yu, Peng ^{[1
]}

机构：

[1] Tianjin Univ Sci & Technol, Coll Biotechnol,China Int Sci & Technol Cooperat, Tianjin Int Cooperat Res Ctr Food Nutr Safety & M, Tianjin Enterprise Key Lab Applicat Res Hyaluron, Tianjin, Peoples R China

[2] CNRS, UMR 8232, Inst Parisien Chim Mol, Paris, France

来源：

DRUG DELIVERY | 2020年 / 27卷 / 01期

关键词：

F7; topotecan; thermosensitive liposome; tumor hyperthermia; co-delivery; LOCALIZED DELIVERY; TRIGGERED RELEASE; IN-VITRO; NANOPARTICLES; DOXORUBICIN; VINCRISTINE; FORMULATION; THERAPY; DESIGN; VIVO;

D O I：

10.1080/10717544.2020.1772409

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In order to enhance the targeting efficiency and reduce anti-tumor drug's side effects, topotecan (TPT) and F7 were co-loaded in thermosensitive liposomes (F7-TPT-TSL), which show enhanced permeability and retention in tumors, as well as local controlled release by heatingin vitro. TPT is a water-soluble inhibitor of topoisomerase I that is converted to an inactive carboxylate structure under physiological conditions (pH 7.4). F7 is a novel drug significantly resistant to cyclin-dependent kinase but its use was restricted by its high toxicity. F7-TPT-TSL had excellent particle distribution (about 103 nm), high entrapment efficiency (>95%), obvious thermosensitive property, and good stability. Confocal microscopy demonstrated specific higher accumulation of TSL in tumor cells. MTT proved F7-TPT-TSL/H had strongest cell lethality compared with other formulations. Then therapeutic efficacy revealed synergism of TPT and F7 co-loaded in TSL, together with hyperthermia. Therefore, the F7-TPT-TSL may serve as a promising system for temperature triggered cancer treatment.

引用

页码：836 / 847

页数：12

共 55 条

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