On chip magnetic actuator for batch-mode dynamic manipulation of magnetic particles in compact lab-on-chip

被引：27

作者：

Fulcrand, Remy ^{[1
,2
]}

Bancaud, Aurelien ^{[1
,2
]}

Escriba, Christophe ^{[1
,2
]}

He, Qihao ^{[1
,2
]}

Charlot, Samuel ^{[1
,2
]}

Boukabache, Ali ^{[1
,2
]}

Gue, Anne-Marie ^{[1
,2
]}

机构：

[1] CNRS LAAS, F-31077 Toulouse, France

[2] Univ Toulouse, UPS INSA LAAS, F-31077 Toulouse, France

来源：

SENSORS AND ACTUATORS B-CHEMICAL | 2011年 / 160卷 / 01期

关键词：

Magnetic actuation; Polymer technology; Microbeads; Lab-on-chip; FABRICATION; LAMINATION;

D O I：

10.1016/j.snb.2011.08.011

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The use of magnetic microbeads in microfluidic systems is a promising approach for setting up lab on chips that accomplish a variety of bioanalytical operations. To meet the integration requirements of mu TAS, one challenge is to reduce the size of magnetic effectors in order to increase the complexity of magneto-fluidic systems. In this paper, we report on a new method for manipulating batches of magnetic microbeads with exquisite spatial precision. Our approach is based on arrays of individually addressable micro-electromagnetic actuators, which are integrated in full polymer (SU-8) devices. We define the optimal working range of our technology, demonstrating that 5-turns micro-coils of similar to 100 mu m in dimension efficiently trap 2.8 mu m microbeads in flow rates of similar to 1 mu l/min. Furthermore we estimate quantitatively the magnetic forces generated by these micro-coils, which are on the order of 1-10 pN. Taken together our technology affords reconfigurable and compact solutions for the manipulation of magnetic micro-particles in lab-on-chip applications. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：1520 / 1528

页数：9

共 35 条

[1] A novel fabrication method of flexible and monolithic 3D microfluidic structures using lamination of SU-8 films [J].