Trimethylamine N-oxide as a risk marker for ischemic stroke in patients with atrial fibrillation

被引：47
作者：
Liang, Zhaoguang [1 ]
Dong, Zengxiang [1 ,2 ]
Guo, Meihua [2 ]
Shen, Zhaoqian [1 ]
Yin, Dechun [1 ]
Hu, Shuang [2 ]
Hai, Xin [2 ]
机构：
[1] Harbin Med Univ, Affiliated Hosp 1, Dept Cardiol, Harbin, Heilongjiang, Peoples R China
[2] Harbin Med Univ, Affiliated Hosp 1, Dept Pharm, Harbin 150001, Heilongjiang, Peoples R China
来源：
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY | 2019年 / 33卷 / 02期
基金：
中国国家自然科学基金;
关键词：
atrial fibrillation (AF); ischemic stroke (IS); risk factors; trimethylamine N-oxide (TMAO); INTESTINAL MICROBIOTA; GUT MICROBIOTA; PROGNOSTIC VALUE; MONOOXYGENASE; PHOSPHATIDYLCHOLINE; METABOLITE; MORTALITY; CARNITINE; PATHWAY; CHOLINE;
D O I：
10.1002/jbt.22246
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Trimethylamine N-oxide (TMAO) is an independent risk factor of cardiovascular disease. Our objective was to explore the relation between TMAO and ischemic stroke (IS) in patients with atrial fibrillation (AF). A total of 68 patients with AF with IS and 111 ones without IS were enrolled. The plasma levels of TMAO remarkably increased in IS-AF patients (8.25 +/- 1.58 mu M) compared with patients with AF (2.22 +/- 0.09 mu M, P < 0.01). The receiver operating characteristic analysis revealed that the best cutoff value of TMAO to predict IS in patients with AF was 3.53 mu M with 75.0% sensitivity and 92.8% specificity (area under the curve: 0.917, 95% confidence intervals: 0.877-0.957). Univariate and multivariate logistic regression analysis showed that TMAO was an independent predictor in IS. The level of TMAO was correlated with the CHA2DS2-VASc score. In conclusion, TMAO was an independent predictor of IS, which could potentially refine stroke stratification in patients with AF.
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页数：5
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