Regulation of Drosophila-virus interaction

被引：16
作者：
Fullaondo, Ane [2 ]
Lee, So Young [1 ]
机构：
[1] CIC bioGUNE, Funct Genom Unit, Derio 48160, Spain
[2] CIC bioGUNE, Genome Anal Platform, Derio 48160, Spain
来源：
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY | 2012年 / 36卷 / 02期
关键词：
MicroRNA; Virus; Innate immunity; Drosophila melanogaster; ANTIVIRAL IMMUNITY; PATHWAY; ACTIVATION; INHIBITOR; MICRORNAS; RESPONSES; DEFENSE;
D O I：
10.1016/j.dci.2011.08.007
中图分类号：
S9 [水产、渔业];
学科分类号：
0908 ;
摘要：
Drosophila melanogaster is a useful model system for deciphering mammalian biological processes including development, innate immunity and cancer. Most genetic studies conducted in Drosophila have focused on the immune response against microbial infection and the results obtained have been extrapolated to other organisms. During the last decade the issue of the antiviral response attracted a great deal of interest. In this review we highlight recent discoveries in the role of RNA interference pathway in antiviral response in Drosophila with a focus on the role of miRNAs as both host defense elements and helpers of viral replication. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：262 / 266
页数：5
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