Chemiluminescence-Guided Cancer Therapy Using a Chemiexcited Photosensitizer

被引：263

作者：

Mao, Duo ^{[1
]}

Wu, Wenbo ^{[1
,2
]}

Ji, Shenglu ^{[3
,4
]}

Chen, Chao ^{[3
,4
]}

Hu, Fang ^{[1
]}

Kong, Deling ^{[3
,4
]}

Ding, Dan ^{[3
,4
]}

Liu, Bin ^{[1
]}

机构：

[1] Natl Univ Singapore, Dept Chem & Biomol Engn, 4 Engn Dr 4, Singapore 117585, Singapore

[2] Natl Univ Singapore, Dept Mat Sci & Engn, 7 Engn Dr 1, Singapore 117574, Singapore

[3] Nankai Univ, Minist Educ, State Key Lab Med Chem Biol, Key Lab Bioact Mat, Tianjin 300071, Peoples R China

[4] Nankai Univ, Coll Life Sci, Tianjin 300071, Peoples R China

来源：

CHEM | 2017年 / 3卷 / 06期

基金：

美国国家科学基金会;

关键词：

AGGREGATION-INDUCED EMISSION; LIGHT-UP PROBE; PHOTODYNAMIC THERAPY; HYDROGEN-PEROXIDE; ORGANIC NANOPARTICLES; OXIDATIVE STRESS; TUMOR; ANTICANCER; DOTS; AIE;

D O I：

10.1016/j.chempr.2017.10.002

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Image-guided therapy is one of the most promising strategies for efficiently curing a tumor. Here, a novel nanomaterial with chemiexcited far-red/nearinfrared (FR/NIR) emission and singlet oxygen (O-1(2)) generation is reported for precise diagnosis and treatment of tumors. Bis[2,4,5-trichloro-6-(pentyloxycarbonyl) phenyl] oxalate (CPPO) and a specially designed photosensitizer TBD with aggregation-induced FR/NIR emission were co-encapsulated by pluronic F-127 and soybean oil to form C-TBD nanoparticles (C-TBD NPs). These NPs serve as a specific H2O2 probe to precisely track tumors in vivo through chemiluminescence imaging. In addition, effective O-1(2) generation by C-TBD NPs in response to tumor H2O2 was observed, which could efficiently induce tumor cell apoptosis and inhibit tumor growth. Both the chemiluminescence response and the therapeutic function were further enhanced when b-phenylethyl isothiocyanate was used to enhance the H2O2 production at the tumor site. Our results prove that C-TBD NPs provide a new strategy for intelligent, accurate, and non-invasive tumor therapy.

引用

页码：991 / 1007

页数：17