Epigenetic Control of Embryonic Stem Cell Differentiation

被引：18
作者：
Armstrong, Lyle [1 ]
机构：
[1] Newcastle Univ, Inst Med Genet, Int Ctr Life, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
来源：
STEM CELL REVIEWS AND REPORTS | 2012年 / 8卷 / 01期
关键词：
Pluripotent stem cells; Epigenetics; Histone modification; DNA methylation; Cell differentiation; Somatic cells; CHROMATIN-STRUCTURE; GENE-EXPRESSION; DEVELOPMENTAL REGULATION; HISTONE MODIFICATIONS; DNA METHYLATION; SELF-RENEWAL; HOX GENES; PLURIPOTENT; MOUSE; TRANSCRIPTION;
D O I：
10.1007/s12015-011-9300-4
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Pluripotent embryonic stem cells can give rise to almost all somatic cell types but this characteristic requires precise control of their gene expression patterns. The necessity of keeping the entire genome "poised" to enter into any of a number of developmental possibilities requires a unique and highly plastic chromatin organisation based around specific patterns of histone modifications although this state of affairs is normally short lived during embryonic development. By deriving embryonic stem cells from the early embryo, we can preserve the highly specialised genome organisation and this has permitted several detailed investigations into the molecular basis of pluripotency.
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收藏
页码：67 / 77
页数：11
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