Exploring the potential of the β-thiolactones in bioorganic chemistry

被引：16

作者：

Aubry, Sylvain ^{[1
]}

Sasaki, Kaname ^{[1
]}

Eloy, Laure ^{[1
]}

Aubert, Genevieve ^{[1
]}

Retailleau, Pascal ^{[1
]}

Cresteil, Thierry ^{[1
]}

Crich, David ^{[1
]}

机构：

[1] CNRS, Inst Chim Subst Nat, Ctr Rech Gif, F-91190 Gif Sur Yvette, France

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2011年 / 9卷 / 20期

关键词：

CYSTEINE PROTEINASE-INHIBITORS; FREE-RADICAL CHEMISTRY; PROTEASOME INHIBITORS; SALINOSPORAMIDE-A; MOLECULAR-STRUCTURE; COUPLING REACTIONS; CANCER-THERAPY; ACTIVE-SITE; CATHEPSIN-B; LACTONES;

D O I：

10.1039/c1ob05967j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of novel peptide-based beta-thiolactones were synthesized and assayed for cytotoxicity against several human cancer cell lines, where they showed greater activity than the corresponding beta-lactones and beta-lactams. Several of the beta-thiolactones prepared showed strong inhibitory activity in vitro against human cathepsins B and L.

引用

页码：7134 / 7143

页数：10

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