Changes in hepatitis A virus seroepidemiology in HIV-infected Brazilian patients

被引：6

作者：

Aloise, R. ^{[1
]}

de Almeida, A. J. ^{[1
,2
]}

Sion, F. S. ^{[2
]}

Morais-de-Sa, C. A. ^{[2
]}

Gaspar, A. M. C. ^{[1
]}

de Paula, V. S. ^{[1
]}

机构：

[1] Fiocruz MS, Viral Technol Lab, Inst Oswaldo Cruz, Dept Virol, BR-21041210 Rio De Janeiro, Brazil

[2] Univ Fed Estado Rio de Janeiro, Gaffree & Guinle Univ Hosp, Med Clin B, Rio de Janeiro, Brazil

来源：

INTERNATIONAL JOURNAL OF STD & AIDS | 2008年 / 19卷 / 05期

关键词：

hepatitis A virus; HIV/AIDS; HIV/HAV co-infection; Brazil;

D O I：

10.1258/ijsa.2007.007100

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Shifting of hepatitis A virus (HAV) epidemiology from a high towards an intermediate endemicity pattern and use of antiretroviral therapy increased the risk of HIV/HAV coinfection in developing countries. The aim of this study was to investigate the presence of HAV markers in a cohort of HIV-infected patients from 1988 to 2004. The presence of serum anti-HAV antibodies and HAV-RNA by real-time polymerase chain reaction was investigated in 581 patients. Total anti-HAV antibodies was found in 464/581 (79.8%) patients, however, a changing epidemiologic pattern of hepatitis A among HIV-infected patients from 1988 to 2004 was observed. Among patients susceptible to HAV (n=117), 5 (4.2%) were coinfected with HAV, all of them had IgM anti-HAV antibodies and were serum HAV-RNA-positive. The high prevalence of anti-HAV antibodies in HIV-infected patients suggests that screening tests for anti-HAV antibodies should be performed before implementation of hepatitis A vaccination, especially in those patients from endemic countries.

引用

页码：321 / 326

页数：6

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