Diagnostic Evaluation in Aspirin-Exacerbated Respiratory Disease

被引：5

作者：

Williams, Adam N. ^{[1
,2
,3
]}

机构：

[1] Bend Mem Clin, Dept Allergy Asthma & Immunol, 815 Southwest Bond St, Bend, OR 97702 USA

[2] Oregon Hlth & Sci Univ, Sch Med, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA

[3] Bend Mem Clin, 815 Southwest Bond St, Bend, OR 97702 USA

来源：

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA | 2016年 / 36卷 / 04期

关键词：

Aspirin-exacerbated respiratory disease; Diagnosis; NSAID hypersensitivity; Chronic rhinosinusitis with nasal polyps; Asthma; Intranasal ketorolac; Oral aspirin challenge; Lysine-aspirin; PERIPHERAL-BLOOD LEUKOCYTES; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; LEUKOTRIENE-MODIFIER DRUGS; NASAL PROVOCATION TEST; IN-VITRO DIAGNOSIS; INDUCED ASTHMA; SENSITIVE ASTHMATICS; BASOPHIL ACTIVATION; CYSTEINYL LEUKOTRIENES; LYSINE-ASPIRIN;

D O I：

10.1016/j.iac.2016.06.003

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Aspirin-exacerbated respiratory disease (AERD) is a distinct clinical condition characterized by chronic sinusitis with nasal polyps, asthma, and hypersensitivity reactions to nonsteroidal anti-inflammatory drugs (NSAIDs). Distinguishing AERD from other forms of chronic sinusitis, asthma, and NSAID reactivity has important clinical implications for management. The clinical history is helpful, but not adequate for confirming the diagnosis of AERD, in most cases. Diagnostic provocation challenge remains the only way to confirm or exclude the diagnosis of AERD. This article discusses the utility of the clinical history and the current evidence regarding measures that optimize the safety of performing diagnostic NSAID provocation challenges.

引用

页码：657 / +

页数：14

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