Copper-catalyzed direct oxidative synthesis of α-ketoamides from aryl methyl ketones, amines, and molecular oxygen

被引：156

作者：

Du, Feng-Tian ^{[1
,2
]}

Ji, Jian-Xin ^{[1
]}

机构：

[1] Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China

[2] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China

来源：

CHEMICAL SCIENCE | 2012年 / 3卷 / 02期

基金：

中国国家自然科学基金;

关键词：

DOUBLE CARBONYLATION; CYCLOTHEONAMIDE-B; AMIDE INHIBITORS; SINGLET OXYGEN; CORE STRUCTURE; DERIVATIVES; CLEAVAGE; ENAMINES; COMPLEX; SUPEROXIDE;

D O I：

10.1039/c1sc00312g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel and efficient copper-catalyzed direct oxidative synthesis of alpha-ketoamides from aryl methyl ketones, amines, and molecular oxygen has been developed under mild and neat conditions. O-18 labeling experiments revealed that both oxygen atoms of the alpha-ketoamides derived from molecular oxygen.

引用

页码：460 / 465

页数：6

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