SYNTHESIS AND ANTITUBERCULOSIS ACTIVITY OF DERIVATIVES OF THE DITERPENOID ISOSTEVIOL WITH AZINE, HYDRAZIDE, AND HYDRAZONE MOIETIES

被引：10

作者：

Garifullin, B. F. ^{[1
]}

Strobykina, I. Yu ^{[1
]}

Mordovskoi, G. G. ^{[2
]}

Mironov, V. F. ^{[1
]}

Kataev, V. E. ^{[1
]}

机构：

[1] Russian Acad Sci, Kazan Sci Ctr, AE Arbuzov Organ & Phys Chem Inst, Kazan 420088, Russia

[2] Ural Sci Res Inst Phtisiopulmonol, Ekaterinburg 620039, Russia

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2011年 / 47卷 / 01期

关键词：

diterpenoids; ent-beyerane; isosteviol; hydrazides; M; tuberculosis; antituberculosis activity; ANTIMYCOBACTERIAL ACTIVITY; ANTIMALARIAL; TUBERCULOSIS; CONSTITUENTS; ACIDS;

D O I：

10.1007/s10600-011-9829-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Derivatives of the diterpenoid isosteviol (16-oxo-ent-beyeran-19-oic acid) with azine, hydrazone, and hydrazide moieties were synthesized. They exhibited high tuberculostatic activity in vitro against the strain Mycobacterium tuberculosis H(37)R(V) (minimum inhibiting concentration in the range 6.3-1.7 mu g/mL).

引用

页码：55 / 58

页数：4

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