Multilayered, Hyaluronic Acid-Based Hydrogel Formulations Suitable for Automated 3D High Throughput Drug Screening of Cancer-Stromal Cell Cocultures

被引：48
作者：
Engel, Brian J. [1 ]
Constantinou, Pamela E. [1 ]
Sablatura, Lindsey K. [1 ]
Doty, Nathaniel J. [2 ]
Carson, Daniel D. [1 ]
Farach-Carson, Mary C. [1 ]
Harrington, Daniel A. [1 ]
Zarembinski, Thomas I. [2 ]
机构：
[1] Rice Univ, Dept Biosci, Houston, TX 77005 USA
[2] BioTime Inc, Alameda, CA 94502 USA
来源：
ADVANCED HEALTHCARE MATERIALS | 2015年 / 4卷 / 11期
关键词：
3D culture; coculture; drug screening; high throughput; hyaluronic acid; IN-VITRO; 3-DIMENSIONAL CULTURE; GROWTH; MATRIX; POLYSACCHARIDE; RESISTANCE; INHIBITION; EXPRESSION; RECEPTOR; DISTINCT;
D O I：
10.1002/adhm.201500258
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Validation of a high-throughput compatible 3D hyaluronic acid hydrogel coculture of cancer cells with stromal cells. The multilayered hyaluronic acid hydrogels improve drug screening predictability as evaluated with a panel of clinically relevant chemotherapeutics in both prostate and endometrial cancer cell lines compared to 2D culture. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：1664 / 1674
页数：11
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