Multilayered, Hyaluronic Acid-Based Hydrogel Formulations Suitable for Automated 3D High Throughput Drug Screening of Cancer-Stromal Cell Cocultures

被引：48

作者：

Engel, Brian J. ^{[1
]}

Constantinou, Pamela E. ^{[1
]}

Sablatura, Lindsey K. ^{[1
]}

Doty, Nathaniel J. ^{[2
]}

Carson, Daniel D. ^{[1
]}

Farach-Carson, Mary C. ^{[1
]}

Harrington, Daniel A. ^{[1
]}

Zarembinski, Thomas I. ^{[2
]}

机构：

[1] Rice Univ, Dept Biosci, Houston, TX 77005 USA

[2] BioTime Inc, Alameda, CA 94502 USA

来源：

ADVANCED HEALTHCARE MATERIALS | 2015年 / 4卷 / 11期

关键词：

3D culture; coculture; drug screening; high throughput; hyaluronic acid; IN-VITRO; 3-DIMENSIONAL CULTURE; GROWTH; MATRIX; POLYSACCHARIDE; RESISTANCE; INHIBITION; EXPRESSION; RECEPTOR; DISTINCT;

D O I：

10.1002/adhm.201500258

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Validation of a high-throughput compatible 3D hyaluronic acid hydrogel coculture of cancer cells with stromal cells. The multilayered hyaluronic acid hydrogels improve drug screening predictability as evaluated with a panel of clinically relevant chemotherapeutics in both prostate and endometrial cancer cell lines compared to 2D culture. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

收藏

页码：1664 / 1674

页数：11

相关论文

共 57 条

[1]

Afify Alaa M, 2005, Ann Diagn Pathol, V9, P312, DOI 10.1016/j.anndiagpath.2005.07.004

[2] Cell anchorage and the cytoskeleton as partners in growth factor dependent cell cycle progression [J].

Assoian, RK ;

Zhu, XY .

CURRENT OPINION IN CELL BIOLOGY, 1997, 9 (01) :93-98

[3] Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (Macrophage-Colony stimulating factor) production and breast tumor progression [J].

Bourguignon, LYW ;

Singleton, PA ;

Zhu, HB ;

Diedrich, F .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (32) :29420-29434

[4] Hyaluronan promotes signaling interaction between CD44 and the transforming growth factor β receptor I in metastatic breast tumor cells [J].

Bourguignon, LYW ;

Singleton, PA ;

Zhu, HB ;

Zhou, B .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (42) :39703-39712

[5] Hyaluronic Acid Hydrogels for Biomedical Applications [J].

Burdick, Jason A. ;

Prestwich, Glenn D. .

ADVANCED MATERIALS, 2011, 23 (12) :H41-H56

[6] Injectable glycosaminoglycan hydrogels for controlled release of human basic fibroblast growth factor [J].

Cai, SS ;

Liu, YC ;

Shu, XZ ;

Prestwich, GD .

BIOMATERIALS, 2005, 26 (30) :6054-6067

[7] 3D Cultures of Prostate Cancer Cells Cultured in a Novel High-Throughput Culture Platform Are More Resistant to Chemotherapeutics Compared to Cells Cultured in Monolayer [J].

Chambers, Karen F. ;

Mosaad, Eman M. O. ;

Russell, Pamela J. ;

Clements, Judith A. ;

Doran, Michael R. .

PLOS ONE, 2014, 9 (11)

[8] The resistance of intracellular mediators to doxorubicin and cisplatin are distinct in 3D and 2D endometrial cancer [J].

Chitcholtan, Kenny ;

Sykes, Peter H. ;

Evans, John J. .

JOURNAL OF TRANSLATIONAL MEDICINE, 2012, 10

[9] Biology of bone marrow stroma [J].

Clark, BR ;

Keating, A .

BONE MARROW TRANSPLANTATION: FOUNDATIONS FOR THE 21ST CENTURY, 1995, 770 :70-78

[10] Hyaluronan: A simple polysaccharide with diverse biological functions [J].

Dicker, Kevin T. ;

Gurski, Lisa A. ;

Pradhan-Bhatt, Swati ;

Witt, Robert L. ;

Farach-Carson, Mary C. ;

Jia, Xinqiao .

ACTA BIOMATERIALIA, 2014, 10 (04) :1558-1570

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