Crystal structures and physico-chemical properties of Zn(II) and Co(II) tetraaqua(3-nitro-4-hydroxybenzoato) complexes:: Their anticonvulsant activities as well as related (5-nitrosalicylato)-metal complexes

被引：79

作者：

d'Angelo, Jean ^{[1
]}

Morgant, Georges ^{[1
]}

Ghermani, Nour Eddine ^{[2
,3
]}

Desmaele, Didier ^{[1
]}

Fraisse, Bernard ^{[3
]}

Bonhomme, Francois ^{[2
]}

Dichi, Emma ^{[4
]}

Sghaier, Mehrez ^{[4
]}

Li, Yanling ^{[5
]}

Journaux, Yves ^{[5
]}

Sorenson, John R. J. ^{[6
]}

机构：

[1] Univ Paris Sud, Fac Pharm, Lab BioCIS, CNRS,UMR 8076,IFR 141, F-92296 Chatenay Malabry, France

[2] Univ Paris Sud, Fac Pharm, Lab PPB, CNRS,UMR 8612,IFR 141, F-92296 Chatenay Malabry, France

[3] Ecole Cent Paris, Lab SPMS, CNRS, UMR 8580, F-92295 Chatenay Malabry, France

[4] Univ Paris Sud, Fac Pharm, Lab CPMB, F-92296 Chatenay Malabry, France

[5] Univ Paris 06, Lab CIMM, CNRS, UMR 7071, F-75005 Paris, France

[6] Univ Arkansas, Dept Pharmaceut Sci, Div Med Chem, Little Rock, AR 72205 USA

来源：

POLYHEDRON | 2008年 / 27卷 / 02期

关键词：

crystal structures; 3-Nitro-4-hydroxybenzoic acid ligand; Zn(II) and Co(II) complexes; anticonvulsant activity;

D O I：

10.1016/j.poly.2007.10.006

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Purposes of these studies were to synthesize Zn(II) and Co(II) complexes of 3-nitro-4-hydroxybenzoic acid, determine their structures through X-ray crystallography, and obtain their anticonvulsant activities. Thermogravimetric, differential scanning calorimetry, impedance of aqueous solutions and magnetic properties analyses were also determined. Anticonvulsant and related activities of these complexes as well as Zn(II), Co(II), Ni(II) and Mg(II) (5-nitrosalicylato) complexes were determined by the National Institutes of Health, Antiepileptic Development Program. Results of these analyses are presented to document unique bonding features and physical properties of these compounds and their anticonvulsant activities. It is concluded that these compounds have chemical and physical properties that can be used to account for their anticonvulsant activities. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：537 / 546

页数：10

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