LTP in CA1 of the adult rat hippocampus and voltage-activated calcium channels

被引：14

作者：

Izumi, Y

Zorumski, CF

机构：

[1] Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Dept Neurobiol, St Louis, MO 63110 USA

来源：

NEUROREPORT | 1998年 / 9卷 / 16期

关键词：

ageing; development; hippocampus; synaptic plasticity;

D O I：

10.1097/00001756-199811160-00022

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

IT is difficult to induce long-term potentiation (LTP) in CA1 of hippocampal slices from 120-day-oId rats when a single 100 Hz, 1 s tetanus is administered in extracellular solution containing 2.0 mM calcium and 2.0 mM magnesium. However, in the presence of 2.5 mM calcium and 1.3 mM magnesium LTP is reliably induced by this same stimulus. Although the amplitude of LTP is similar to that observed in slices from 30-day-old rats, LTP in slices from mature rats is not inhibited by MK-801 but is blocked by nifedipine. These results suggest that factors contributing to LTP in slices from mature rats require careful consideration under different experimental paradigms. NeuroReport 9: 3689-3691 (C) 1998 Lippincott Williams & Wilkins.

引用

页码：3689 / 3691

页数：3

共 16 条

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