Immediate neurophysiological effects of transcranial electrical stimulation

被引：358

作者：

Liu, Anli ^{[1
,2
]}

Voroslakos, Mihaly ^{[3
,4
]}

Kronberg, Greg ^{[5
]}

Henin, Simon ^{[1
,2
]}

Krause, Matthew R. ^{[6
]}

Huang, Yu ^{[5
]}

Opitz, Alexander ^{[7
]}

Mehta, Ashesh ^{[8
,9
]}

Pack, Christopher C. ^{[6
]}

Krekelberg, Bart ^{[10
]}

Berenyi, Antal ^{[3
]}

Parra, Lucas C. ^{[5
]}

Melloni, Lucia ^{[1
,2
,11
]}

Devinsky, Orrin ^{[1
,2
]}

Buzsaki, Gyorgy ^{[4
]}

机构：

[1] NYU, Comprehens Epilepsy Ctr, 223 34th St, New York, NY 10016 USA

[2] NYU Langone Hlth, Dept Neurol, 222 East 41st St,14th Floor, New York, NY 10016 USA

[3] Univ Szeged, Dept Physiol, MTA SZTE Momentum Oscillatory Neuronal Networks R, Fac Med, 10 Dom Sq, H-6720 Szeged, Hungary

[4] NYU, Neurosci Inst, 435 East 30th St, New York, NY 10016 USA

[5] CUNY City Coll, Dept Biomed Engn, 160 Convent Ave, New York, NY 10031 USA

[6] McGill Univ, Montreal Neurol Inst, Montreal, PQ H3A 2B4, Canada

[7] Dept Biomed Engn Minnesota, 312 Church St SE, Minneapolis, MN 55455 USA

[8] Hofstra Northwell Sch Med, Dept Neurosurg, 611 Northern Blvd, Great Neck, NY 11021 USA

[9] Hofstra Northwell Sch Med, Feinstein Inst Med Res, 350 Community Dr, Manhasset, NY 11030 USA

[10] Rutgers State Univ, Ctr Mol & Behav Neurosci, 197 Univ Ave, Newark, NJ 07102 USA

[11] Max Planck Inst Empir Aesthet, Gruneburgweg 14, D-60322 Frankfurt, Germany

来源：

NATURE COMMUNICATIONS | 2018年 / 9卷

关键词：

MOTOR CORTEX STIMULATION; CENTRAL NERVOUS-SYSTEM; IN-VIVO MEASUREMENT; CEREBRAL-CORTEX; CORTICAL EXCITABILITY; VISUAL-CORTEX; FIELDS; BRAIN; OSCILLATIONS; MODULATION;

D O I：

10.1038/s41467-018-07233-7

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Noninvasive brain stimulation techniques are used in experimental and clinical fields for their potential effects on brain network dynamics and behavior. Transcranial electrical stimulation (TES), including transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS), has gained popularity because of its convenience and potential as a chronic therapy. However, a mechanistic understanding of TES has lagged behind its widespread adoption. Here, we review data and modelling on the immediate neurophysiological effects of TES in vitro as well as in vivo in both humans and other animals. While it remains unclear how typical TES protocols affect neural activity, we propose that validated models of current flow should inform study design and artifacts should be carefully excluded during signal recording and analysis. Potential indirect effects of TES (e.g., peripheral stimulation) should be investigated in more detail and further explored in experimental designs. We also consider how novel technologies may stimulate the next generation of TES experiments and devices, thus enhancing validity, specificity, and reproducibility.

引用

页数：12

共 130 条

[1] Ephaptic coupling of cortical neurons [J].