Associative learning in deficit and nondeficit schizophrenia

被引：29

作者：

Farkas, Marta ^{[1
]}

Polgar, Patricia ^{[1
]}

Kelemen, Oguz ^{[2
]}

Rethelyi, Janos ^{[1
]}

Bitter, Istvan ^{[1
]}

Myers, Catherine E. ^{[4
]}

Gluck, Mark A. ^{[3
]}

Keri, Szabolcs ^{[1
]}

机构：

[1] Semmelweis Univ, Dept Psychiat & Psychotherapy, H-1083 Budapest, Hungary

[2] Bacs Kiskun Country Hosp, Psychiat Unit, Kecskemet, Hungary

[3] Rutgers State Univ, Ctr Neurosci, Newark, NY USA

[4] Rutgers State Univ, Dept Psychol, Newark, NY USA

来源：

NEUROREPORT | 2008年 / 19卷 / 01期

关键词：

acquired equivalence; basal ganglia; cognition; learning; schizophrenia;

D O I：

10.1097/WNR.0b013e3282f2dff6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

When two stimuli are associated and treated as equivalent, generalization occurs between them (acquired equivalence). The feedback-guided learning of associations is related to the basal ganglia, whereas the medial temporal lobe participates in acquired equivalence learning. In this study, we investigated feedback-guided associative learning was impaired only in deficit patients. Associative learning and acquired equivalence were not related to frontal lobe tests. These results suggest that the enduring negative symptoms of deficit patients may be related to decreased response to cognitive feedback and deficient basal ganglia functioning.

引用

页码：55 / 58

页数：4

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