Chinese Consensus Report on Family-Based Helicobacter pylori Infection Control and Management (2021 Edition)

被引：121

作者：

Ding, Song-Ze ^{[1
,2
]}

Du, Yi-Qi ^{[3
]}

Lu, Hong ^{[4
]}

Wang, Wei-Hong ^{[5
]}

Cheng, Hong ^{[5
]}

Chen, Shi-Yao ^{[6
]}

Chen, Min-Hu ^{[7
]}

Chen, Wei-Chang ^{[8
]}

Chen, Ye ^{[9
]}

Fang, Jing-Yuan ^{[10
]}

Gao, Heng-Jun ^{[11
]}

Guo, Ming-Zhou ^{[12
]}

Han, Ying ^{[13
]}

Hou, Xiao-Hua ^{[14
]}

Hu, Fu-Lian ^{[5
]}

Jiang, Bo ^{[15
]}

Jiang, Hai-Xing ^{[16
]}

Lan, Chun-Hui ^{[17
]}

Li, Jing-Nan ^{[18
]}

Li, Yan ^{[19
]}

Li, Yan-Qing ^{[20
]}

Liu, Jie ^{[21
]}

Li, You-Ming ^{[22
]}

Lyu, Bin ^{[23
]}

Lu, You-Yong ^{[24
]}

Miao, Ying-Lei ^{[25
]}

Nie, Yong-Zhan ^{[26
]}

Qian, Jia-Ming ^{[18
]}

Sheng, Jian-Qiu ^{[27
]}

Tang, Cheng-Wei ^{[28
]}

Wang, Fen ^{[29
,30
]}

Wang, Hua-Hong ^{[5
]}

Wang, Jiang-Bin ^{[31
]}

Wang, Jing-Tong ^{[32
]}

Wang, Jun-Ping ^{[33
]}

Wang, Xue-Hong ^{[34
]}

Wu, Kai-Chun ^{[35
]}

Xia, Xing-Zhou ^{[36
]}

Xie, Wei-Fen ^{[37
]}

Xie, Yong ^{[38
]}

Xu, Jian-Ming ^{[39
]}

Yang, Chang-Qing ^{[40
]}

Yang, Gui-Bin ^{[41
]}

Yuan, Yuan ^{[42
]}

Zeng, Zhi-Rong ^{[43
]}

Zhang, Bing-Yong ^{[44
]}

Zhang, Gui-Ying ^{[45
]}

Zhang, Guo-Xin ^{[46
]}

Zhang, Jian-Zhong ^{[47
]}

Zhang, Zhen-Yu ^{[48
]}

机构：

[1] Zhengzhou Univ, Peoples Hosp, Dept Gastroenterol & Hepatol, Zhengzhou, Henan, Peoples R China

[2] Henan Univ, Peoples Hosp, Dept Gastroenterol & Hepatol, Kaifeng, Henan, Peoples R China

[3] Naval Med Univ, Changhai Hosp, Gastroenterol Div, Shanghai, Peoples R China

[4] Shanghai Jiao Tong Univ, Renji Hosp, Shanghai Inst Digest Diseas, GI Div,Sch Med, Shanghai, Peoples R China

[5] Peking Univ First Hosp, Dept Gastroenterol & Hepatol, Beijing, Peoples R China

[6] Fudan Univ, Zhongshan Hosp, Dept Gastroenterol & Hepatol, Shanghai, Peoples R China

[7] Sun Yat Sen Univ, Div Gastroenterol & Hepatol, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R China

[8] Soochow Univ, Dept Gastroenterol & Hepatol, Affiliated Hosp 1, Suzhou, Jiangsu, Peoples R China

[9] Southern Med Univ, Nanfang Hosp, Dept Gastroenterol & Hepatol, Guangzhou, Guangdong, Peoples R China

[10] Shanghai Jiao Tong Univ, Renji Hosp, Gastroenterol Div, Shanghai, Peoples R China

[11] Tongji Univ, Sch Med, Dept Gastroenterol & Hepatol, Shanghai, Peoples R China

[12] Chinese Peoples Liberat Army Gen Hosp, Dept Gastroenterol & Hepatol, Beijing, Peoples R China

[13] Chinese Peoples Liberat Army Gen Hosp, Med Ctr 7, Dept Gastroenterol & Hepatol, Beijing, Peoples R China

[14] Huazhong Univ Sci & Technol, Dept Gastroenterol & Hepatol, Tongji Med Coll, Wuhan, Peoples R China

[15] Tsinghua Univ, Changgeng Hosp, Dept Gastroenterol & Hepatol, Beijing, Peoples R China

[16] Guangxi Med Univ, Affiliated Hosp 1, Dept Gastroenterol & Hepatol, Nanning, Guangxi, Peoples R China

[17] Army Med Univ, Daping Hosp, Dept Gastroenterol & Hepatol, Chongqing, Peoples R China

[18] Peking Union Med Coll Hosp, Dept Gastroenterol & Hepatol, Beijing, Peoples R China

[19] China Med Univ, Dept Gastroenterol & Hepatol, Shengjing Hosp, Shenyang, Liaoning, Peoples R China

[20] Shandong Univ, Qilu Hosp, Dept Gastroenterol & Hepatol, Jinan, Shandong, Peoples R China

[21] Fudan Univ, Huashan Hosp, Dept Gastroenterol & Hepatol, Shanghai, Peoples R China

[22] Zhejiang Univ, Affiliated Hosp 1, Dept Gastroenterol & Hepatol, Sch Med, Hangzhou, Zhejiang, Peoples R China

[23] Zhejiang Chinese Med Univ, Affiliated Hosp 1, Dept Gastroenterol & Hepatol, Hangzhou, Zhejiang, Peoples R China

[24] Peking Univ Canc Hosp, Lab Mol Oncol, Key Lab Carcinogenesis & Translat Res, Minist Educ, Beijing, Peoples R China

[25] Kunming Med Univ, Affilliated Hosp 1, Dept Gastroenterol & Hepatol, Kunming, Yunnan, Peoples R China

[26] Air Force Med Univ, Xijing Hosp, Natl Clin Res Ctr Digest Dis, State Key Lab Canc Biol, Xian, Shaanxi, Peoples R China

[27] Chinese Peoples Liberat Army Gen Hosp, Med Ctr 7, Dept Gastroenterol, Beijing, Peoples R China

[28] Sichuan Univ, West China Hosp, Dept Gastroenterol & Hepatol, Chengdu, Sichuan, Peoples R China

[29] Cent South Univ, Xiangya Hosp 3, Dept Gastroenterol & Hepatol, Changsha, Hunan, Peoples R China

[30] Hunan Key Lab Nonresolving Inflammat & Canc, Changsha, Hunan, Peoples R China

[31] Jilin Univ, Dept Gastroenterol & Hepatol, China Japan Union Hosp, Changchun, Jilin, Peoples R China

[32] Peking Univ Third Hosp, Dept Gastroenterol & Hepatol, Beijing, Peoples R China

[33] Shanxi Med Univ, Dept Gastroenterol & Hepatol, Hosp 1, Taiyuan, Shanxi, Peoples R China

[34] Qinghai Univ, Qinghai Univ Hosp, Dept Gastroenterol & Hepatol, Xining, Qinghai, Peoples R China

[35] Air Force Med Univ, Xijing Hosp, Dept Gastroenterol & Hepatol, Xian, Shaanxi, Peoples R China

[36] Zhengzhou Univ, Affiliated Hosp 5, Dept Gastroenterol & Hepatol, Zhengzhou, Henan, Peoples R China

[37] Naval Med Univ, Changzheng Hosp, Dept Gastroenterol, Shanghai, Peoples R China

[38] Nanchang Univ, Dept Gastroenterol & Hepatol, Affiliated Hosp 1, Nanchang, Jiangxi, Peoples R China

[39] Anhui Med Univ, Dept Gastroenterol & Hepatol, Affiliated Hosp 1, Hefei, Anhui, Peoples R China

[40] Tongji Univ, Tongji Hosp, Div Gastroenterol & Hepatol, Shanghai, Peoples R China

[41] Aerosp Cent Hosp, Dept Gastroenterol & Hepatol, Beijing, Peoples R China

[42] China Med Univ, Key Lab GI Canc Etiol & Prevent Liaoning Prov, Affiliated Hosp 1, Shenyang, Liaoning, Peoples R China

[43] Zhongshan Univ, Affiliated Hosp 1, Dept Gastroenterol & Hepatol, Guangzhou, Guangdong, Peoples R China

[44] Cent South Univ, Xiangya Hosp, Dept Gastroenterol & Hepatol, Changsha, Hunan, Peoples R China

[45] Nanjing Med Univ, Affiliated Hosp 1, Dept Gastroenterol & Hepatol, Nanjing, Jiangsu, Peoples R China

[46] Chinese Ctr Dis Control & Prevent, Natl Inst Communicable Dis Control & Prevent, Dept Communicable Dis Diagnost DCDD, Beijing, Peoples R China

[47] Nanjing Med Univ, Nanjing Hosp 1, Dept Gastroenterol & Hepatol, Nanjing, Jiangsu, Peoples R China

[48] Nanchang Univ, Affiliated Hosp 1, Dept Gastroenterol, Nanchang, Jiangxi, Peoples R China

[49] Shandong Univ, Qilu Hosp, Dept Gastroenterol, Jinan, Shandong, Peoples R China

[50] Naval Med Univ, Changhai Hosp, Dept Gastroenterol & Hepatol, Shanghai, Peoples R China

来源：

GUT | 2022年 / 71卷 / 02期

关键词：

helicobacter pylori; gastric cancer; 13C-urea breath test; mucosal infection; gastritis; GASTRIC-CANCER PATIENTS; STOOL ANTIGEN TEST; UREA BREATH TEST; TERM-FOLLOW-UP; SUCCESSFUL ERADICATION; REINFECTION RATE; DUAL THERAPY; RISK-FACTORS; 1ST-DEGREE RELATIVES; DIAGNOSTIC-ACCURACY;

D O I：

10.1136/gutjnl-2021-325630

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Objective Helicobacter pylori infection is mostly a family-based infectious disease. To facilitate its prevention and management, a national consensus meeting was held to review current evidence and propose strategies for population-wide and family-based H. pylori infection control and management to reduce the related disease burden. Methods Fifty-seven experts from 41 major universities and institutions in 20 provinces/regions of mainland China were invited to review evidence and modify statements using Delphi process and grading of recommendations assessment, development and evaluation system. The consensus level was defined as >= 80% for agreement on the proposed statements. Results Experts discussed and modified the original 23 statements on family-based H. pylori infection transmission, control and management, and reached consensus on 16 statements. The final report consists of three parts: (1) H. pylori infection and transmission among family members, (2) prevention and management of H. pylori infection in children and elderly people within households, and (3) strategies for prevention and management of H. pylori infection for family members. In addition to the 'test-and-treat' and 'screen-and-treat' strategies, this consensus also introduced a novel third 'family-based H. pylori infection control and management' strategy to prevent its intrafamilial transmission and development of related diseases. Conclusion H. pylori is transmissible from person to person, and among family members. A family-based H. pylori prevention and eradication strategy would be a suitable approach to prevent its intra-familial transmission and related diseases. The notion and practice would be beneficial not only for Chinese residents but also valuable as a reference for other highly infected areas.

引用

页码：238 / 253

页数：16

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