Self-assembly and emulsification of dopamine-modified hyaluronan

被引：34

作者：

Zhu, Ye ^{[1
]}

Wang, Juanqin ^{[1
]}

Li, Xiaojie ^{[1
,2
]}

Zhao, Donghua ^{[1
]}

Sun, Jianhua ^{[1
]}

Liu, Xiaoya ^{[1
]}

机构：

[1] Jiangnan Univ, Sch Chem & Mat Engn, Key Lab Food Colloids & Biotechnol, Minist Educ, Wuxi 214122, Jiangsu, Peoples R China

[2] Osaka Prefecture Univ, Grad Sch Engn, Dept Appl Chem, Sakai, Osaka 5998531, Japan

来源：

CARBOHYDRATE POLYMERS | 2015年 / 123卷

基金：

美国国家科学基金会;

关键词：

Hyaluronan; Dopamine; Self-assemble; pH-responsive; Pickering emulsion; DRUG-DELIVERY; CROSS-LINKING; EMULSIONS; ACID; PH; PARTICLES; NANOPARTICLES; PERFORMANCE; COPOLYMERS; INVERSION;

D O I：

10.1016/j.carbpol.2015.01.030

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Dopamine modified hyaluronan (HA-DOPA) with different grafting degree were synthesized and self-assembled into nanoparticles. The effects of pH and salinity changes on the structure of the HA-DOPA nanoparticles were investigated. Nanoparticles swelled under increased pH values, and disassociation started at pH values above 6.20. At a fixed pH of 6.20, the size of the nanoparticles decreased with increased salinity, and flocculation occurred when the salt concentration was higher than 0.3 M. The emulsification performance of HA-DOPA nanoparticles at different pH values and salt concentrations demonstrated that nanoparticles with moderately swollen structures possess better emulsifying efficiency and emulsion stability. Additionally, HA-DOPA nanopartides were able to stabilize various types of oils. These results suggest that HA-DOPA nanoparticles have promising potential as Pickering emulsifiers for applications in the cosmetics, medical, and food industries. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：72 / 79

页数：8

共 37 条

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