Self-assembly and emulsification of dopamine-modified hyaluronan

被引：33
作者：
Zhu, Ye [1 ]
Wang, Juanqin [1 ]
Li, Xiaojie [1 ,2 ]
Zhao, Donghua [1 ]
Sun, Jianhua [1 ]
Liu, Xiaoya [1 ]
机构：
[1] Jiangnan Univ, Sch Chem & Mat Engn, Key Lab Food Colloids & Biotechnol, Minist Educ, Wuxi 214122, Jiangsu, Peoples R China
[2] Osaka Prefecture Univ, Grad Sch Engn, Dept Appl Chem, Sakai, Osaka 5998531, Japan
来源：
CARBOHYDRATE POLYMERS | 2015年 / 123卷
基金：
美国国家科学基金会;
关键词：
Hyaluronan; Dopamine; Self-assemble; pH-responsive; Pickering emulsion; DRUG-DELIVERY; CROSS-LINKING; EMULSIONS; ACID; PH; PARTICLES; NANOPARTICLES; PERFORMANCE; COPOLYMERS; INVERSION;
D O I：
10.1016/j.carbpol.2015.01.030
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Dopamine modified hyaluronan (HA-DOPA) with different grafting degree were synthesized and self-assembled into nanoparticles. The effects of pH and salinity changes on the structure of the HA-DOPA nanoparticles were investigated. Nanoparticles swelled under increased pH values, and disassociation started at pH values above 6.20. At a fixed pH of 6.20, the size of the nanoparticles decreased with increased salinity, and flocculation occurred when the salt concentration was higher than 0.3 M. The emulsification performance of HA-DOPA nanoparticles at different pH values and salt concentrations demonstrated that nanoparticles with moderately swollen structures possess better emulsifying efficiency and emulsion stability. Additionally, HA-DOPA nanopartides were able to stabilize various types of oils. These results suggest that HA-DOPA nanoparticles have promising potential as Pickering emulsifiers for applications in the cosmetics, medical, and food industries. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：72 / 79
页数：8
相关论文
共 37 条
  • [1] Formation of Unimer Nanoparticles by Controlling the Self-Association of Hydrophobically Modified Poly(amino acid)s
    Akagi, Takami
    Piyapakorn, Phassamon
    Akashi, Mitsuru
    [J]. LANGMUIR, 2012, 28 (11) : 5249 - 5256
  • [2] Emulsions stabilised solely by colloidal particles
    Aveyard, R
    Binks, BP
    Clint, JH
    [J]. ADVANCES IN COLLOID AND INTERFACE SCIENCE, 2003, 100 : 503 - 546
  • [3] Effects of pH and salt concentration on oil-in-water emulsions stabilized solely by nanocomposite microgel particles
    Binks, BP
    Murakami, R
    Armes, SP
    Fujii, S
    [J]. LANGMUIR, 2006, 22 (05) : 2050 - 2057
  • [4] Inversion of emulsions stabilized solely by ionizable nanoparticles
    Binks, BP
    Rodrigues, JA
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2005, 44 (03) : 441 - 444
  • [5] Catastrophic phase inversion of water-in-oil emulsions stabilized by hydrophobic silica
    Binks, BP
    Lumsdon, SO
    [J]. LANGMUIR, 2000, 16 (06) : 2539 - 2547
  • [6] Particles as surfactants - similarities and differences
    Binks, BP
    [J]. CURRENT OPINION IN COLLOID & INTERFACE SCIENCE, 2002, 7 (1-2) : 21 - 41
  • [7] Emulsions stabilized by stimuli-sensitive poly(N-isopropylacrylamide)-co-methacrylic acid polymers:: Microgels versus low molecular weight polymers
    Brugger, Bastian
    Richtering, Walter
    [J]. LANGMUIR, 2008, 24 (15) : 7769 - 7777
  • [8] Self-assembled hyaluronic acid nanoparticles as a potential drug carrier for cancer therapy: synthesis, characterization, and in vivo biodistribution
    Choi, Ki Young
    Min, Kyung Hyun
    Na, Jin Hee
    Choi, Kuiwon
    Kim, Kwangmeyung
    Park, Jae Hyung
    Kwon, Ick Chan
    Jeong, Seo Young
    [J]. JOURNAL OF MATERIALS CHEMISTRY, 2009, 19 (24) : 4102 - 4107
  • [9] New associative systems based on alkylated hyaluronic acid.: Synthesis and aqueous solution properties
    Creuzet, C
    Kadi, S
    Rinaudo, M
    Auzléy-Velty, R
    [J]. POLYMER, 2006, 47 (08) : 2706 - 2713
  • [10] How does the nature of the steric stabilizer affect the pickering emulsifier performance of lightly cross-linked, acid-swellable poly(2-vinylpyridine) latexes?
    Dupin, Damien
    Armes, Steven P.
    Connan, Carole
    Reeve, Paul
    Baxter, Steven M.
    [J]. LANGMUIR, 2007, 23 (13) : 6903 - 6910
1234