Interrelationship between MYC gene numerical aberrations and protein expression in individuals from northern Brazil with early gastric adenocarcinoma

被引：33

作者：

Raiol, Láuren Cláudia Costa ^{[1
]}

Silva, Evely Cristina Figueira ^{[1
]}

Da Fonseca, Diana Mendes ^{[1
]}

Leal, Mariana Ferreira ^{[2
]}

Guimaraes, Adriana Costa ^{[1
]}

Calcagno, Danielle Queiroz ^{[1
]}

Khayat, André Salim ^{[1
]}

Assumpcao, Paulo Pimentel ^{[3
]}

Smith, Marília De Arruda Cardoso ^{[2
]}

Burbano, Rommel Rodriguez ^{[1
]}

机构：

[1] Fed Univ Para, Inst Biol Sci, Human Cytogenet & Toxicol Genet Lab, BR-66075900 Belem, Para, Brazil

[2] Univ Fed Sao Paulo, Dept Morphol, Div Genet, Sao Paulo, SP, Brazil

[3] Fed Univ Para, Joao Barros Barreto Univ Hosp, Belem, Para, Brazil

来源：

CANCER GENETICS AND CYTOGENETICS | 2008年 / 181卷 / 01期

关键词：

D O I：

10.1016/j.cancergencyto.2007.10.011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Gastric cancer is the second leading cause of death by cancer in Brazil. Early gastric cancer represents similar to 10% of gastric cancer cases in some services of Brazil, which underscores the need for early gastric cancer diagnosis that could lead to better prognosis. There are few published studies of cytogenetic alterations in early gastric cancer. To evaluate MYC copy number and its protein expression, we performed fluorescence in situ hybridization and immunohistochemical analyses in five early gastric adenocarcinomas in individuals from northern Brazil. Three signals of MYC and MYC immunoreactivity were observed in all five samples, regardless of histologic type, tumor extension, or lymph nodal status. These novel findings concerning MYC copy number alteration in early gastric cancer suggest that MYC alteration is observed in the beginning of gastric carcinogenesis and could be used as a therapeutic target. (c) 2008 Elsevier Inc. All rights reserved.

引用

页码：31 / 35

页数：5

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