Insights on the pathophysiology of Alzheimer's disease: The crosstalk between amyloid pathology, neuroinflammation and the peripheral immune system

被引：113

作者：

Da Mesquita, Sandro ^{[1
,2
]}

Ferreira, Ana Catarina ^{[1
,2
]}

Sousa, Joao Carlos ^{[1
,2
]}

Correia-Neves, Margarida ^{[1
,2
]}

Sousa, Nuno ^{[1
,2
]}

Marques, Fernanda ^{[1
,2
]}

机构：

[1] Univ Minho, Sch Hlth Sci, Life & Hlth Sci Res Inst ICVS, Campus Gualtar, P-4710057 Braga, Portugal

[2] ICVS 3Bs PT Govt Associate Lab, Braga, Guimaraes, Portugal

来源：

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 2016年 / 68卷

关键词：

Alzheimer's disease; Aging; Amyloid beta; Cognition; Blood-brain barrier; Choroid plexus; Cerebrospinal fluid; Glial cells; Neurons; Cytokines; Neuroinflammation; Immune system; BLOOD-BRAIN-BARRIER; CENTRAL-NERVOUS-SYSTEM; NECROSIS-FACTOR-ALPHA; CEREBROSPINAL-FLUID A-BETA(42); RECEPTOR-RELATED PROTEIN-1; MILD COGNITIVE IMPAIRMENT; TRANSGENIC MOUSE MODEL; TOLL-LIKE RECEPTORS; FACTOR-KAPPA-B; A-BETA;

D O I：

10.1016/j.neubiorev.2016.06.014

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Alzheimer's disease (AD) is the most common form of dementia, whose prevalence is growing along with the increased life expectancy. Although the accumulation and deposition of amyloid beta (A beta) peptides in the brain is viewed as one of the pathological hallmarks of AD and underlies, at least in part, brain cell dysfunction and behavior alterations, the etiology of this neurodegenerative disease is still poorly understood. Noticeably, increased amyloid load is accompanied by marked inflammatory alterations, both at the level of the brain parenchyma and at the barriers of the brain. However, it is debatable whether the neuroinflammation observed in aging and in AD, together with alterations in the peripheral immune system, are responsible for increased amyloidogenesis, decreased clearance of A beta out of the brain and/or the marked deficits in memory and cognition manifested by AD patients. Herein, we scrutinize some important traits of the pathophysiology of aging and AD, focusing on the interplay between the amyloidogenic pathway, neuroinflammation and the peripheral immune system. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：547 / 562

页数：16

共 266 条

[1] β-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase [J].