Brief report: Tolerance and chimerism after renal and hematopoietic-cell transplantation

被引：382

作者：

Scandling, John D. ^{[1
]}

Busque, Stephan ^{[2
]}

Dejbakhsh-Jones, Sussan ^{[1
]}

Benike, Claudia ^{[3
]}

Millan, Maria T. ^{[2
]}

Shizuru, Judith A. ^{[1
]}

Hoppe, Richard T. ^{[4
]}

Lowsky, Robert ^{[1
]}

Engleman, Edgar G. ^{[3
]}

Strober, Samuel ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Med, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Dept Surg, Stanford, CA 94305 USA

[3] Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA

[4] Stanford Univ, Sch Med, Dept Radiat Oncol, Stanford, CA 94305 USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2008年 / 358卷 / 04期

关键词：

D O I：

10.1056/NEJMoa074191

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We describe a recipient of combined kidney and hematopoietic-cell transplants from an HLA-matched donor. A post-transplantation conditioning regimen of total lymphoid irradiation and antithymocyte globulin allowed engraftment of the donor's hematopoietic cells. The patient had persistent mixed chimerism, and the function of the kidney allograft has been normal for more than 28 months since discontinuation of all immunosuppressive drugs. Adverse events requiring hospitalization ware limited to a 2-day episode of fever with neutropenia. The patient has had neither rejection episodes nor clinical manifestations of graft-versus-host disease.

引用

页码：362 / 368

页数：7

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